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Topic: Clinical Characteristics and Health Care Setting
January 7, 2021
Outcomes of COVID-19 in Hospitalized Solid Organ Transplant Recipients Compared to a Matched Cohort of Non-Transplant Patients at a National Healthcare System in the United States
Solid organ transplant (SOT) recipients with COVID-19 were more likely to experience adverse outcomes than matched non-SOT recipients in a cohort study conducted between March and September 2020. SOT recipients (n=128) were 1.9 times more likely to die within the study period compared to non-SOT patients (n=3,907). SOT recipients were also more than twice as…
Insight into the Reason of Prolonged Viral RNA Shedding in Patients with COVID-19 Infection
A cohort study (n=681) in Italy found that older age was independently associated with prolonged viral shedding. Patients who first had two consecutive negative nasopharyngeal swabs 1-2 days apart within <3 weeks, 3-6 weeks, and >6 weeks, had a mean age of 50.5 years, 57 years, and 65.8 years, respectively (p<0.05). Bongiovanni et al. (Jan…
January 6, 2021
Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospital Workers: Results From a Screening Study in New Jersey, United States in Spring 2020
A study of SARS-CoV-2 seroprevalence in hospital workers in New Jersey found that healthcare workers at highest risk for infection included support staff and people from underrepresented minority populations, with and without patient care responsibilities. The proportion of participants testing positive was highest for phlebotomists (23.9%), maintenance/housekeeping (17.3%), dining/food services (16.9%), and interpersonal/support roles (13.7%)…
Saliva Viral Load Is a Dynamic Unifying Correlate of COVID-19 Severity and Mortality
[Pre-print, not-peer reviewed] In a cohort of 154 hospitalized patients, salivary viral load showed a superior ability over nasopharyngeal viral load to predict mortality over time (AUC=0.90). Salivary viral load was positively associated with COVID-19 inflammatory markers and type 1 immune response cytokines and higher viral loads strongly correlated with depletion of platelets, lymphocytes, and…
January 5, 2021
Risk Factors Associated With All-Cause 30-Day Mortality in Nursing Home Residents With COVID-19
A cohort study of 5,256 nursing home residents with COVID-19 found that increased age, male sex, and impaired cognitive and physical function were independent risk factors for all-cause 30-day mortality. Residents aged 80-84 years had 1.5-times the risk of death compared to those aged 75-79 years. Women were 31% less likely to die than men….
Accuracy of the Veterans Health Administration COVID-19 (VACO) Index for Predicting Short-Term Mortality among 1307 Yale New Haven Hospital Inpatients and 427224 Medicare Patients
[Pre-print, not peer reviewed] The Veterans Health Administration COVID-19 (VACO) Index was shown to accurately estimate risk of short-term mortality among a wide variety of patients. The index was validated using 1,307 Yale New Haven Hospital inpatients and over 420,000 Medicare patients and consistently identified those at greatest relative risk of death. The authors suggest…
A National US Survey of Pediatric Emergency Department Coronavirus Pandemic Preparedness
Pediatric emergency departments (PEDs) experienced decreases of non-COVID-19 patients and implemented modifications to staffing, workflow and clinical practice. According to a survey of 25 departments, 60% had COVID-19-dedicated units and 32% modified their pediatric patient age to include adults. All PEDs changed their staffing model, with 80% of PEDs implementing changes affecting physicians. 62% reported…
January 4, 2021
Mortality in Hospitalized Patients with Cancer and Coronavirus Disease 2019: A Systematic Review and Meta‐analysis of Cohort Studies
A systematic review and meta-analysis of the effects of COVID-19 on the clinical outcomes of patients with cancer indicated that the pooled 30‐day mortality rate from 13 primarily inpatient studies (n=2922 patients) was 30%. The overall pooled 30‐day mortality risk from 5 studies that included a mixture of inpatient and outpatient populations (n=624 patients) was…
Racial Disparities in COVID-19 Hospitalizations Do Not Lead to Disparities in Outcomes
A retrospective study of 799 patients hospitalized with COVID-19 in Michigan showed that while Black patients had disproportionately higher rates of hospitalization, mortality was not higher in Black patients in multivariate analysis (aOR=0.61). Black patients tended to be younger (62.9 years vs. 71.8), had a higher mean body mass index (32.4 kg/m2 vs 28.8), had higher prevalence…
December 30, 2020
COVID‐19 Infection Prevention and Control Adherence in Long‐term Care Facilities, Atlanta, Georgia
Long-term care facilities (LTCF) with greater implementation of infection prevention and control (IPC) had a lower prevalence of COVID-19, according to analysis of 24 facilities in Fulton County, GA. Specifically, significant differences were observed in prevalence of implementation of IPCs belonging to the social distancing category (high prevalence LTCF, 54% vs low prevalence LTCFs, 74%)…
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