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Topic: Clinical Characteristics and Health Care Setting
May 14, 2021
Short-Term Antibody Response Afer 1 Dose of BNT162b2 Vaccine in Patients Receiving Hemodialysis
A study of persons receiving onsite hemodialysis and health care worker controls (N=210) found that a single dose of the Pfizer-BioNTech vaccine failed to elicit detectable IgG antibodies in 57% of hemodialysis patients and 5% of health care workers without previous SARS-CoV-2 infection at 4 weeks following vaccination. Among hemodialysis patients with previous SARS-CoV-2 infection,…
May 13, 2021
Evaluation of Healthcare Personnel Exposures to Patients with SARS-CoV-2 Associated with Personal Protective Equipment Use
Lack of eye protection during the care of a COVID-19 patient was associated with test positivity for SARS-CoV-2 infection (RR=10) among 345 healthcare personnel (HCP) who sustained significant occupational exposure to COVID-19 patients in a tertiary care center in Minnesota from May to November 2020. While the most common reason for significant exposure was use…
May 12, 2021
Evolution of COVID-19 Symptoms during the First 9 Months after Illness Onset
[Pre-print, not peer-reviewed] In a cohort of COVID-19 patients from the Netherlands (n=301) 82% of patients recovering from severe/critical disease reported at least one persistent symptom 12 weeks after illness onset, compared to 33% and 64% among those recovering from mild to moderate disease, respectively. At nine months after illness onset, 42% of participants continued…
Trends over Time in the Risk of Adverse Outcomes among Patients with SARS-CoV-2 Infection
In the 30 days following a positive SARS-CoV-2 test, a decline in hospitalization (44% to 16%) and death (20% to 5%) was observed between February and July 2020 in a cohort of enrollees in the US Veterans Affairs healthcare system (n=55,952). Similar trends were also observed for 30-day incidence for ICU admission and mechanical ventilation….
May 11, 2021
Severe COVID-19 in People with Type 1 and Type 2 Diabetes in Sweden: A Nationwide Retrospective Cohort Study
Type 2 diabetes was associated with increased risk of COVID-19-related hospitalization (HR=2.22), admission to ICU (HR=2.49), and death (HR=2.19) in a nationwide study in Sweden that compared adult patients with type 2 diabetes (n=44,639) to age- and sex-matched controls. Risks for COVID-19 related outcomes remained independently associated with type 2 diabetes after further adjustment for…
Characteristics of Patients Discharged and Readmitted after COVID-19 Hospitalisation within a Large Integrated Health System in the United States
The 30-day readmission rate for patients admitted to hospital with COVID-19 among patients who belong to an integrated healthcare system (Kaiser Permanente) was 8% (n=166) in a retrospective cohort of 2,180 patients between April to July 2020. 58% of readmissions were respiratory-related and occurred a median of 5 days after discharge. Chronic pulmonary disease and…
Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium
Neurological manifestations were found in 82% of patients hospitalized with COVID-19 in a cohort study across 2 consortia of patients from 13 countries (n=3,744). The most common self-reported symptoms included headache (37%) and loss of smell or taste (26%), while the most prevalent neurological signs and/or syndromes were acute encephalopathy (49%), coma (17%), and stroke…
May 10, 2021
Reverse-Transcribed SARS-CoV-2 RNA Can Integrate into the Genome of Cultured Human Cells and Can Be Expressed in Patient-Derived Tissues
A study using RNA sequencing found evidence to suggest that SARS-CoV-2 RNA may be able to integrate into human cell genomes in vitro, perhaps explaining the persistence of viral RNA among patients even after recovery from COVID-19. The authors found evidence that suggests viral–host chimeric transcripts are created via long interspersed nuclear elements, which reverse-transcribe…
Self-Reported Smell and Taste Recovery in Coronavirus Disease 2019 Patients: A One-Year Prospective Study
More than 20% of patients surveyed in Italy who recovered from mild-to-moderate symptomatic COVID-19 reported altered sense of smell or taste one year after initial symptom onset (prevalence = 57/286, 21%). 34 participants reported both smell and taste dysfunction, while 15 reported smell impairment alone and 5 taste disorder alone after 1 year. Of 187…
May 7, 2021
Prevalence and Outcomes of Co-Infection and Superinfection with SARS-CoV-2 and Other Pathogens: A Systematic Review and Meta-Analysis
A meta-analysis of 118 studies reporting the clinical features and outcomes of persons with SARS CoV-2 infection found that up to 19% had co-infections (pathogens detected at the time of SARS CoV-2 diagnosis) and 24% had superinfections (other pathogens detected during SARS-CoV-2 care). Persons with co- and super-infections had a higher risk of mortality (OR…
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