Result for
Topic: Geographic Spread
February 16, 2021
Analysis of SARS-CoV-2 Mutations in the United States Suggests Presence of Four Substrains and Novel Variants
Whole genome sequencing of 12,754 SARS-CoV-2 sequences from the US suggests the presence of 4 substrains and 11 most frequent mutations as of September 11, 2020. The 2 most common mutations are also the top 2 in the world (D614G mutation in the spike protein and the P323L mutation), both of which were detected in…
February 13, 2021
Before the Surge Molecular Evidence of SARS-CoV-2 in New York City Prior to the First Report
[pre-print; not peer-reviewed] SARS-CoV-2 RNA was found in pooled nasopharyngeal specimens collected from 3,040 people in New York City in the week ending January 25, 2020, suggesting that the virus was present in the city a month before the first officially documented case. The authors were also able to reconstruct phylogenetic relationships between seven complete…
February 11, 2021
Imported SARS-COV-2 Variant P.1 Detected in Traveler Returning from Brazil to Italy
An imported case of the P.1 SARS-CoV-2 variant (also known as the B.1.1.28 or 20J/501Y.V3 variant) was detected in an asymptomatic passenger traveling on an indirect flight from Brazil to Italy on January 17, 2021. The case patient and his family received PCR-negative results at the departure airport in Brazil, and was tested on January…
Novel SARS-CoV-2 Variant Identified in Travelers from Brazil to Japan
A novel SARS-CoV-2 strain was detected in 4 travelers flying from Brazil to Japan on January 2, 2021. Whole genome sequencing suggests the variant descends from the P.1 lineage with 12 nonsynonymous mutations in the receptor-binding domain (RBD) of the spike protein, including the K417T, E484K, and N501Y mutations also present in the B.1.1.7 and…
February 9, 2021
Emergence of an Early SARS-CoV-2 Epidemic in the United States
[Pre-print, not peer-reviewed] Genome sequencing combined with epidemiological and mobility data suggest show that SARS-COV-2 was likely introduced in Louisiana from a single source via domestic travel and was being locally spread prior to the Mardi Gras celebrations in February 2020. However, further evidence suggests that Mardi Gras was likely a superspreading event, based on…
UK coronavirus variant detected at the UW (Message to Seattle students and employees)
[Press release, not peer-reviewed] The B.1.1.7 variant (first described in the UK) was identified in a sample obtained from a University of Washington student in late January 2021. Genetic sequencing occurred as part of the Husky Coronavirus Testing program and was performed on February 8, 2021. The student is doing well and out of their…
February 8, 2021
Genomic Epidemiology Identifies Emergence and Rapid Transmission of SARS-CoV-2 B.1.1.7 in the United States
[Pre-print, not peer-reviewed] Sequencing of 212 B.1.1.7 SARS-CoV-2 variant genomes collected from testing facilities in the U.S. between December 2020 to January 2021 found that while the proportion of B.1.1.7 variants among S gene target failure samples varied by state, detection of the variant had a doubling rate of a little over a week and…
February 3, 2021
Sixteen Novel Lineages of SARS-CoV-2 in South Africa
An analysis of 1,365 SARS-CoV-2 genomic sequences in South Africa identified 16 new lineages of the virus isolated between March 6 and August 26, 2020. Three lineages (B.1.1.54, B.1.1.56 and C.1) were responsible for 42% of all infections in South Africa during the first wave, during which 42 detectable lineages were circulating throughout the country….
January 21, 2021
Emergence of a Novel SARS-CoV-2 Strain in Southern California USA
[pre-print, not peer reviewed] A novel SARS-CoV-2 strain, CAL.20C, emerging from Southern California, was detected through genome sequence analysis. The strain’s increasing dominance has coincided with an increased positivity rate in that region. While first observed in July, CAL.20C accounted for 24% of cases by December 2020. CAL.20C is characterized by multiple mutations in the…
Genomic Epidemiology of SARS-CoV-2 Reveals Multiple Lineages and Early Spread of SARS-CoV-2 Infections in Lombardy, Italy
Sequence analysis of 346 whole SARS-CoV-2 genomes collected from Italy suggest that up to 7 viral lineages were circulating in the country between February and April 2020. Two lineages likely originated from Italy, including the B.1 lineage that is hypothesized to have given rise to variants emerging from the UK and South Africa. Local transmission…
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