Alliance for Pandemic Preparedness

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Topic: Non-Pharmaceutical Interventions


June 8, 2021

Portable HEPA Purifiers to Eliminate Airborne SARS-CoV-2: A Systematic Review

A systematic review of 11 studies found that portable HEPA purifiers were able to significantly reduce airborne SARS-CoV-2-surrogate particles. Experimental parameters varied considerably, including room sizes varying from 14.75 to 108 m3, and surrogate particle size from 0.012um to <1mm. Overall, HEPA filter-based personal air cleaners were overall the most efficient in removing surrogate particles…


June 7, 2021

Early Epidemiological Evidence of Public Health Value of WA Notify a Smartphone-Based Exposure Notification Tool Modeling COVID-19 Cases Averted in Washington State

[Pre-print, not peer-reviewed] A study of the impact of Washington State’s exposure notification tool, WA Notify, in mitigating the spread of COVID-19 during the first four months of implementation found that based on an estimated COVID-19 case fatality of 1.4%, WA Notify saved 30-120 lives over this period. A model was run on a range…


May 27, 2021

Impacts of Social Distancing Policies on Mobility and COVID-19 Case Growth in the US

State-level emergency declarations early in the COVID-19 pandemic (early March 2020) were associated with a 10% reduction in time spent away from places of residence, according to an analysis of anonymized mobility data from opted-in Google users aggregated at the county level. Subsequent implementation of physical distancing policies and shelter-in-place mandates resulted in additional 25%…


Serial Intervals and Case Isolation Delays for COVID-19: A Systematic Review and Meta-Analysis

The serial interval for COVID-19 (the interval between successive cases in a chain of transmission) ranged from 1 to 10 days in a systematic review and meta-analysis of 56 studies including 129 estimates. A separate systematic review and meta-analysis of 18 studies found that the case isolation delay interval (delay between a case diagnosis and…


May 21, 2021

The Impact of Covid-19 State Closure Orders on Consumer Spending, Employment, and Business Revenue

An analysis of COVID-19 state closure orders found that although these policies led to decreases in consumer spending, business revenue, and employment, they accounted for a small proportion of observed decreases in these outcomes in the early months of the pandemic. The analysis used a difference-in-difference model to examine geographic and temporal variation in these…


May 18, 2021

Adherence to Masking Requirement During the COVID-19 Pandemic by Early Elementary School Children

Observed mask adherence was on average 77% throughout a school day among pre-K to 2nd grade students participating in in-school instruction in an observational survey (n=1,000) across 15 private schools in Atlanta, GA during Fall 2020. Mask adherence, as observed by teachers for 1,048 classroom days, was lowest among Pre-K students (50-60%) and highest among…


May 13, 2021

Results of a Shortened Quarantine Protocol on a Midwestern College Campus

No evidence of onward SARS-CoV-2 transmission was observed among college students released from quarantine after 7 days at the University of Notre Dame between September and November 2020. The 7-day quarantine protocol required both a negative PCR test on day 4 and a negative antigen test on day 7. Among 1,130 asymptomatic contacts of index…


Guidance for Fully Vaccinated People

The CDC released updated guidance as of May 13, 2021 that fully vaccinated individuals (2 weeks after a single dose vaccine or 2 weeks after the second dose of a 2-dose vaccine) no longer need to wear face coverings or physically distance in most indoor and outdoor settings regardless of crowd size. Officials at the…


May 6, 2021

Revelations from the Clinic: Protective Behaviors and Perceptions among People at High Risk for Severe Illness from COVID-19

A survey conducted among residents in rural Michigan (n=150) found that those classified as being at high risk for COVID-19 did not respond significantly differently regarding their level of concern about the pandemic or protective behaviors compared to healthy controls. Among high-risk individuals, no significant differences were observed between those who acknowledged their status (n=73)…


May 4, 2021

Are the Portable Air Cleaners (PAC) Really Effective to Terminate Airborne SARS-CoV-2?

Air sampling in residential rooms of COVID-19 patients (n=7) in Spain showed that 100% of samples were positive for SARS-CoV-2 RNA (cycle threshold (Ct) cutoff 41), but only 15% (1 of 7) of samples were positive after installation of a portable air cleaner (PAC) with a HEPA filter. Notably, the one positive sample after installation…



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