Result for
Topic: Testing and Treatment
March 27, 2020
Serological diagnostic kit of SARS-C 1 oV-2 antibodies using CHO2 expressed full-length SARS-CoV-2 S1 proteins.
The authors report on the development and validation of a SARS-CoV-2 serology ELISA kit for detection of total anti-virus antibody in suspected cases and potentially using this as an at-home testing kit. Sensitivity and specificity of the ELISA kit were both 97.5%, and the kit was used to successfully identify antibodies in a patient who…
March 26, 2020
False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases.
This case study presents two false negative results of real-time RT-PCR which is regarded as the gold standard method for confirming SARS-CoV-2 infection. The study discusses using complementary approaches such as computed tomography (CT) in combination with rRT-PCR to achieve more reliable diagnosis. Li et al. (Apr 2020). False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain…
Rapid Response to COVID-19: Health Informatics Support for Outbreak Management in an Academic Health System.
Reeves et al outline the design and implementation of EHR based rapid screening processes, laboratory testing, clinical decision support, reporting tools, and patient-facing technology related to COVID-19; and highlight the essential role of EHR in supporting clinical needs of a health system during this outbreak. Reeves et al. (Mar 24, 2020). Rapid Response to COVID-19:…
March 25, 2020
Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study
This study investigate the potential association between cardiac injury and in-hospital mortality in a cohort of 110 COVID-19 patients from one hospital in Wuhan, China. Cardiac injury was a risk factor for in-hospital death, while higher oxygen saturation was found to be protective. This may help clinicians identify patients with adverse outcome at the early…
March 24, 2020
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
To et al ascertain the serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal (deep throat) saliva samples from 30 patients with COVID-19 from 2 Hong Kong hospitals, and serum antibody responses in this cohort study. Posterior oropharyngeal saliva specimens are non-invasive and acceptable to patients and can be used for initial diagnosis and subsequent…
COVID-19 outbreak: less stethoscope, more ultrasound.
This article suggests that lung ultrasound is equally effective as a chest X-ray in detecting lung pathologies, and recommend using it to reduce COVID-19 exposure from patients to HCWs. Buonsenso et al. (Mar 20, 2020). COVID-19 outbreak: less stethoscope, more ultrasound. Lancet Respiratory Med. https://doi.org/10.1016/S2213-2600(20)30120-X
Can a Paper-Based Device Trace COVID-19 Sources with Wastewater-Based Epidemiology
The authors propose an alternative method to test for SARS-CoV-2 infection using wastewater-based epidemiology, an approach to predict potential spread by testing for infectious agents in wastewater. They developed a paper-based analytic tool to detect SARS-CoV-2 in wastewater on site while providing near real-time and continuous data, and potentially serve as an early warning system…
March 23, 2020
The feasibility of convalescent plasma therapy in severe COVID- 19 patients: a pilot study
Results from a pilot study based on 19 severe COVID-19 patients indicate that convalescent plasma therapy may have a potential therapeutic effect and low risk in the treatment of severe cases. Duan et al. (Mar 16, 2020). The feasibility of convalescent plasma therapy in severe COVID- 19 patients: a pilot study. Pre-print downloaded Mar 23…
Effectiveness and safety of antiviral or antibody treatments for coronavirus.
The authors conducted a comprehensive literature review on the effectiveness and safety of antiviral therapies for COVID-19 and found that the current evidence on the effectiveness and safety of antiviral therapies is inconclusive. In particular, ribavirin has not shown conclusive effectiveness and may cause harmful adverse events. Rios et al. (Mar 19, 2020). Effectiveness and…
AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system in four weeks
The authors describe their experience in building and deploying an AI system in China that automatically analyzes CT images to detect COVID-19 pneumonia features for faster examination. They report high sensitivity (97%) and high specificity (92%) using the test dataset. Authors of another study on AI applications for COVID-19 provide a machine learning based diagnosis…
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