Result for
Topic: Virology
February 5, 2020
Genomic variance of the 2019-nCoV coronavirus
Ceraolo and Giorgi construct an expansive phylogenetic tree of representative coronaviridae. They confirm a >99% match among sequenced 2019-nCov isolates; and a 96.2% match between 2019-nCoV and the most closely-related bat coronavirus. While 2019-nCoV sequences were fairly homogenous, at least two hyper-variable genomic areas were identified (ORF 1ab, silent; ORF8, serine/leucine variation). They also assessed…
Preliminary identification of potential vaccine targets for 2019-nCoV based on SARS-CoV immunological studies
Using previously described similarities between 2019-nCoV and SARS-CoV, Ahmed, et al. used SARS-CoV-derived experimentally-determined B- and T-cell epitope data to find epitopes in the S and N structural proteins of 2019-nCoV that were identical between the two viruses. Epitopes are parts of the virus “seen” by the immune system. By finding comparable sites across the…
February 4, 2020
An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies
Jiang, et al. provide a review of sequence homologies among SARS, MERS, and bat-SL-CoV’s related to 2019-nCoV strains in order to predict the potential utility of viral replication inhibitors found effective for SARS and MERS in animal models They align 2019-nCoV S protein sequence with those of SARS-CoV and several bat-SL-CoVs to predict the cleavage…
Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV)
Huang and Herrman perform large-scale protein-protein docking experiments to quantify the interactions of 2019-nCoV S-protein receptor-binding domain (S-RBD) with human receptor ACE2 Sampling a large number of thermodynamically probable binding conformations with Monte Carlo algorithm, they established an experiment-based strength reference for evaluating the receptor-binding affinity of 2019-nCoV via comparison with SARS-CoV. The binding affinity…
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