Launched in August 2022, the Research Alliance in Implementation Science to End HIV (RAISE) is a National Institutes of Health-funded supplement to the University of Washington/Fred Hutch Center for AIDS Research (UW/Fred Hutch CFAR) (NIH grant number AI027757). The initiative works to advance the contribution of implementation science (IS) working towards Ending the HIV Epidemic (EHE) by providing technical assistance, forging new collaborations, and building capacity of health departments in EHE jurisdictions. RAISE is led by Dr. Kenneth Sherr in close collaboration with Dr. Matthew Golden, Dr. Christine Khosropour, Dr. Arianna Means and a distinguished group of expert consultants. Providing IS technical assistance to EHE-funded research projects, RAISE contributes to efforts improve the uptake and effectiveness of HIV/AIDS interventions and bend the curve on the HIV epidemic in the US. RAISE also works in partnership with the National Alliance of State and Territorial AIDS Directors (NASTAD) to provide technical assistance to health departments. The RAISE-NASTAD platform links health departments with implementation researchers to promote new research collaborations that are responsive to health department needs, enhance the impact of EHE-supported implementation efforts, and build a long-term collaborative infrastructure for implementation science. RAISE is one of several EHE implementation science hubs across the country, all coordinated by the HIV Implementation Science Coordination Initiative at Northwestern University. For a full list of the other hubs, see here.