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James O. Phillips, Ph.D.
Dr. Phillips is a vestibular neurophysiologist with expertise in neural brainstem recording in awake behaving primates. Dr. Phillips is also an expert on vestibular behavioral testing in human and non-human primates, and on development of vestibular function. Dr. Phillips will direct the research program and be responsible for the coordination of the acute and chronic recording studies, as well as the development of multiunit recording in deep brainstem structures and implementation of the chronic stimulation device. Dr. Phillips has administrative experience as director of two clinical services at the University of Washington and Children’s Hosptial, and as a PI and Co-Pi. Dr. Phillips will oversee and participate in both neural recording and behavioral experiments, analysis of data and publication of results from these studies.
Research Experience (top)±
Rushmer, D.S., Russell, C.J., MacPherson, J.M., Phillips, J.O., Dunbar, D.C. Automatic postural responses in the cat: responses to headward and tailward translation. Exp. Brain Res. 50:45-61, 1983.
Phillips, J.O., Robinson, F.R., Fuchs, A.F. Two-dimensional eye movement and vestibular responses in primate brainstem. Ann. N.Y Acad. Sci. , 656: 950-953, 1992
Coble, E.T., Ling, L., Phillips, J.O., Fuchs, A.F. The role of omni-pause neurons during gaze shifts. In: Visual and oculomotor functions, advances in eye movement research. Edited by J. Van Rensbergen and G. d'Ydewalle. Amsterdam: Elsevier / North Holland, 1994, p. 285-293.,
Phillips, J.O., Ling, L., Siebold, C., Fuchs, A.F. Gaze movements during sinusoidal tracking and body rotation. I. A comparison between head free and head fixed responses in normal monkeys. In: Contemporary ocular motor and vestibular research. Edited by A.F. Fuchs et al. Stuttgart: Georg Thieme Verlag, 1994, p. 265-268.
Ling, L., Phillips, J.O., Siebold, C., Fuchs, A.F. Gaze movements during sinusoidal tracking and body rotation. III. A computational exploration of pursuit and VOR interactions. In: Contemporary ocular motor and vestibular research. Edited by A.F. Fuchs et al. Stuttgart: Georg Thieme Verlag, 1994, p. 182-184.
Siebold, C., Ling, L., Phillips, J.O., Fuchs, A.F., Duckert, L.G. Gaze movements during sinusoidal tracking and body rotation. II. A comparison between normal and canal plugged monkeys. In: Contemporary ocular motor and vestibular research. Edited by A.F. Fuchs et al. Stuttgart: Georg Thieme Verlag, 1994, p. 268-270.
Robinson, F.R., Phillips, J.O., Fuchs, A.F. Coordination of gaze shifts in primates: brainstem inputs to neck and extraocular motoneuron pools. J. Comp. Neurol. , 364: 43-62, 1994.
Phillips, J.O., Ling, L., Fuchs, A.F., Siebold, C., Plorde, J.J. Rapid horizontal gaze movement in the monkey. J. Neurophysiol. 73 (4): 1632-1652, 1995.
Phillips, J.O., Ling, L., Siebold, C., Fuchs, A.F., and Newlands, S. Responses of vestibular neurons during passive and active head and eye movement in the primate. Ann. N.Y Acad. Sci. , 781: 276-291, 1996
Phillips, J.O., Finocchio, D.V., Ong, L., and Fuchs, A.F. Smooth Pursuit in 1- to 4-Month Old Human Infants. Vision Research, 37(21): 3009-3020, 1997
Phillips, J.O., Fuchs, A., Ling, L., Iwamoto, Y., Votaw, S. Gain adaptation of eye and head movement components of simian gaze shifts. J. Neurophysiol., 78: 2817-2821, 1997
Newlands, S.D., Ling, L., Phillips, J.O., Siebold, C., Duckert, L. and Fuchs, A.F. Short- and long-term consequences of canal plugging on gaze shifts in the rhesus monkey. I. Effects on gaze stabilization. J Neurophysiol. 81: 2119-2130, 1999
Phillips, J.O., Ling, L., and Fuchs, A.F. Behavior of the brainstem burst generator during gaze shifts. I. Discharge patterns of omnidirectional pause neurons. J Neurophysiol 81: 1284-1295, 1999
Ling, L., Fuchs, A.F., Phillips, J.O, Freedman, E.G. Apparent dissociation between saccadic eye movements and the firing patterns of premotor neurons and motoneurons. J Neurophysiol. 82: 2808-2811, 1999
Parker, D.E., Phillips, J.O. Self-motion perception: assessment by real-time computer-generated animations, Applied Ergonomics 32 (1) (2001) pp. 31-38.
Weiss, A.F., Kelly, J.P., Phillips, J.O. The infant who is visually unresponsive on a cortical basis. Ophthalmology. 108: 2076-87, 2001
Phillips, J.O., Backous, DD. Evaluation of vestibular function in young children. Otolaryngologic Clinics of North America, 35: 765-790, 2002
L Ling, J.O. Phillips, C. Siebold Examining the paradoxical relation between number of spikes and gaze amplitude in abducens neurons. Ann. N.Y Acad. Sci., 1004:158-168, 2003
Duh , H.B, Parker , D.E., Phillips, J.O., Furness, T.A. "Conflicting" motion cues at the frequency of cross-over between the visual and vestibular self-motion systems evoke simulator sickness. Human Factors , 46:142-153, 2004
Fuchs AF, Ling L, Phillips JO. Behavior of position-vestibular pause (PVP) interneurons of the vestibulo-ocular reflex during head-free gaze shifts in the monkey J Neurophysiol. 94(6):4481-90, 2005
Street, V.A., Kallman, J.C., Robertson, N.G., Kuo, S.F., Morton, C.C., Phillips, J.O. A novel DFNA9 mutation in the VWFA2 domain of COCH alters a conserved cysteine residue and intrachain disulfide bond formation resulting in progressive hearing loss and site-specific vestibular and central oculomotor dysfunction. American Journal of Medical Genetics, 139(2):86-95, 2005
Weiss, A.H., Phillips, J.O. Congenital and compensated vestibular dysfunction in childhood: an overlooked entity. J Child Neurol, 21(7):572-9, 2006
Weiss AH, Phillips JO. Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. Arch Ophthalmol. 124(8):1128-34 2006
027500 - Phillips, JO, Principal Investigator
Prediction of eye movements following craniofacial surgery.
Marsha Sloan Glazier Fund
EY00745-26 - Fuchs, AF, Principal Investigator, Phillips, JO, Co-investigator
Neurophysiology of the oculomotor system.
NIH-National Eye Institute
002004 - Phillips, JO, Principal Investigator
Evaluation of vestibular function in hearing impaired infants and children.
Royalty Research Fund
110838 - Gates, GA, Principal Investigator, Phillips, JO, Co-Investigator
Pharmacotherapy of Meniere’s Disease
American Otological Society Research Fund
NIH DC05175-01 - Fuchs, AF, Principal Investigator, Phillips, JO, Co-Investigator
Vestibular Influences on Movement
NSF 0214744 - Fuchs, AF, Phillips, JO, Co-Investigator
Conference: Vestibular Influences on Movement, San Juan Islands, September 22-26, 2002
National Science Foundation
NIH-DC005368-01A1 - Gates, GA, Principal Investigator, Phillips, JO, Co-Investigator
Barany Society XXII
NIH HD35465 - Dawson, G, Principal Investigator, Phillips, JO, Consultant
Neurobiology and Genetics of Autism: Project II Precursors to language
NIH MH066399 - Dawson, G, Principal Investigator, Phillips, JO, Consultant
UW Autism research center of Excellence: Project II Precursors to Language
NIH - Guralnick, M. Principal Investigator, Phillips JO, Investigator
Rare Disease Research Center for Developmental and Degenerative Disorders of the Cerebellum. P30 Supplement to Mental Retardation and Developmental Disabilities Research Center at the University of Washington
NASA NNA04CC60G - Phillips, JO, Principal Investigator
Gravitational Influence on Cerebellar Control of Gaze Movement and Adaptation
NAAR - Webb S, Principal Investigator UW, Phillips, JO, Principal Investigator CHRMC
Linking Cerebellar Pathology to Functioning in Individuals with Autism: Implications for Translational Research
NIH R21 - Kaneko, CRS, Principal Investigator, Phillips JO, Co-Investigator
Vestibular and optokinetic testing for research and clinic.
NIDCD, Shannon Award