Russell Lab
Division of Hematology, School of Medicine, University of Washington

Selected Russell Lab Papers

Stem Cell Engineering AAV-Mediated Gene Targeting Vector Integration and Genotoxicity
Foamy Virus Vectors AAV Vector Biology and Serotypes Ancient History
ref list
 

Stem Cell Engineering

Riolobos, L., Hirata, R.K., Turtle, C.J., Wang, P.R., Gornalusse, G.G., Zavajlevski, M., Riddell, S.R., and Russell, D.W. (2013). HLA engineering of human pluripotent stem cells. Mol. Ther. 21:1232-1241. PMCID: PMC3677304

Li, B.L., Chang, K.H., Wang, P.R., Hirata, R.K., Papayannopoulou, T., and Russell, D.W. (2012). Trisomy correction in Down Syndrome induced pluripotent stem cells. Cell Stem Cell 11:615-619. PMCID: PMC3705773

Deyle, D.R., Khan, I.F., Ren, G., Wang, P.R., Kho, J., Schwarze, U., and Russell, D.W. (2012). Normal collagen and bone production by gene-targeted human Osteogenesis Imperfecta iPSCs. Mol. Ther. 20:204-213.PMID: 22031238

Khan, I.F., Hirata, R.K., Wang, P.R., Li, Y., Kho, J., Nelson, A., Huo, Y., Zavajlevski, M., Ware, C., and Russell, D.W. (2010). Engineering of human pluripotent stem cells by AAV-mediated gene targeting. Mol. Ther. 18:1192-1199. PMC2889726

Lamba, D.A., McUsic, A., Hirata, R.K., Wang, P.R., Russell, D.W. and Reh, T.A. (2010). Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE. 5:e8763. PMC2808350

Chang, K.H., Huang, A., Hirata, R.K., Wang, P.R., Han H., Li, Q., Russell, D.W. and Papayannopoulou, T. (2010). Globin phenotype of erythroid cells derived from human induced pluripotent stem cells. Blood. 115:2553-2554. PMC2845905

Chamberlain, J.R., Deyle, D.R., Schwarze, U., Wang, P., Hirata, R.K., Li, Y., Byers, P.H., and Russell, D.W. (2008).Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta.Mol. Ther. 16:187-193. PMID: 17955022

Gharwan, H., Hirata, R.K., Wang, P., Richard, R.E., Wang, L., Olson, E., Allen, J., Ware, C.B., and Russell, D.W. (2007).Transduction of human embryonic stem cells by foamy virus vectors. Mol. Ther. 15:1827-1833. PMID: 17622243

Chamberlain, J.R., Schwarze, U., Wang, P., Hirata, R.K., Hankenson, K.D., Pace, J.M., Underwood, R.A., Song, K.M., Sussman, M., Byers, P.H., and Russell, D.W. (2004). Gene targeting in stem cells from individuals with osteogenesis imperfecta.Science 303:1198-1201. PMID: 14976317

Vassilopoulos, G., Wang, P., and Russell, D.W. (2003). Transplanted bone marrow regenerates liver by cell fusion. Nature 422:901-904. PMID: 12665833

 

AAV-Mediated Gene Targeting

Deyle, D.R., Li, L.B., Ren, G., and Russell, D.W. (In press). The effects of polymorphisms on human gene targeting. Nucl. Acids Res. 38:

Wang, P.R., Xu, M., Toffanin, S., Li, Y., Llovett, J.M., and Russell, D.W. (2012). Induction of hepatocellular carcinoma by in vivo gene targeting. Proc. Natl. Acad. Sci. USA.109:11264-11269.

Khan, I.F., Hirata, R.K., and Russell, D.W. (2011). AAV-mediated gene targeting methods for human cells. Nat.Protoc.6:482-501. PMID: 21455185

Cornea, A.M., and Russell, D.W. (2010). Chromosomal position effects on AAV-mediated gene targeting. Nucl. Acids Res.38:3582-3594. PMC2887962

Russell, D.W., and Hirata, R. K. (2008).Human gene targeting favors insertions over deletions. Hum. Gene Ther. 19:907-914. PMC2940567

Fernandez, S.L., Russell, D.W., and Hurlin, P.J. (2007). Development of human gene reporter cell lines using rAAV-mediated homologous recombination.Biol. Proced. Online 9:84-90.PMC2374725

Miller, D.G., Wang, P., Petek, L.M., Hirata, R.K., Sands, M.S., and Russell, D.W. (2006). Gene targeting in vivo by adeno-associated virus vectors. Nat. Biotechnol. 24:1022-1026. PMID: 16878127

Hendrie, P.C., and Russell, D.W. (2005). Gene targeting with viral vectors. Mol. Ther. 12:9-17 PMID: 15932801

Trobridge, G., Hirata, R.K., and Russell, D.W. (2005). Gene targeting by adeno-associated virus vectors is cell-cycle dependent. Hum. Gene Ther. 16:522-526. PMID: 15871683

Hirata, R.H., Xu, C., Dong, R., Miller, D.G., Ferguson, S., and Russell, D.W. (2004). Efficient PRNP gene targeting in bovine fibroblasts by adeno-associated virus vectors.Cloning Stem Cells 6:31-36. PMID: 15107244

Hendrie, P.C., Hirata, R.K, and Russell, D.W. (2003). Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus Minute Virus of Mice. J. Virol. 77:13136-13145. PMC296056

Miller, D.G., Petek, L.M., and Russell, D.W. (2003).Human gene targeting by adeno-associated virus vectors is enhanced by DNA double strand breaks. Mol. Cell. Biol. 23:3550-3557. PMC164770

Hirata, R.K., Chamberlain, J.C., Dong, R., and Russell, D.W. (2002).Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat. Biotechnol. 20:735-738. PMID: 12089561

Russell, D.W., Hirata, R.K., and Inoue, N. (2002). Validation of AAV-mediated gene targeting. Nat. Biotechnol. 20:658.

Inoue, N., Dong, R., Hirata, R. K., and Russell, D.W. (2001). Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors.Mol. Ther. 3:526-530. PMID: 11319913

Hirata, R.K., and Russell, D.W. (2000). Design and packaging of adeno-associated virus gene targeting vectors. J. Virol.74: 4612-4620. PMC11198

Inoue, N., Hirata, R.K., and Russell, D.W.(1999).High-fidelity correction of mutations at multiple chromosomal positions by viral vectors.J. Virol.73:7376-7380. PMC104264

Russell, D.W., and Hirata, R.K.(1998).Human gene targeting by viral vectors.Nat. Genet. 18:325-330. PMC3010411

 

Vector Integration and Genotoxicity

Deyle, D.R., Khan, I.F., Ren, G., and Russell, D.W.(2013). Lack of genotoxicity due to foamy virus vector integration in human iPSCs. Mol. Ther. 20:868-873. PMCID: PMC3655141

Petek, L.M., Russell, D.W., and Miller, D.G. (2010). Frequent endonuclease cleavage at off-target locations in vivo. Mol. Ther.18:983-986. PMC2890094

Hu, J., Renaud, G., Golmes, T., Ferris, A., Hendrie, P.C., Donahue, R.E., Hughes, S.H., Wolfsberg, T., Russell, D.W., and Dunbar, C.E. (2008). Evidence for reduced genotoxicity for avian leucosis sarcoma virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors. Mol. Ther. 16:1617-1623. PMC2561952

Hendrie, P.C., Huo, Y., Stolitenko, R.B., and Russell D.W. (2008).A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses. Mol. Ther.16:534-540. PMID: 18209733

Russell, D.W.(2007). AAV vectors, insertional mutagenesis and cancer. Mol. Ther. 15:1740-1743. PMID: 17882145

Donsante, A., Miller, D.G., Li, Y., Vogler, C., Brunt, E.M., *Russell, D.W., and *Sands, M.S. (2007).AAV vector integration sites in mouse hepatocellular carcinoma. Science 317:477. (*co-corresponding authors) PMID: 17656716

Miller, D.G., Trobridge, G., Petek, L.M., Jacobs, M.A., Kaul, R., and Russell, D.W. (2005). Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J. Virol.79:11434-11442. PMC1193581

Miller, D.G., Petek, L., and Russell, D.W. (2004). Adeno-associated virus vectors integrate at chromosome breakage sites. Nat. Genet. 36:767-773. PMID: 15208627

Miller, D.G., Rutledge, E.A., and Russell, D.W. (2002). Chromosomal effects of adeno-associated virus vector integration. Nat. Genet. 30:147-148. PMID: 11799395

Rutledge, E.A., and Russell, D.W. (1997).Adeno-associated virus vector integration junctions. J. Virol. 71:8429-8436. PMC192305

 

AAV Vector Biology and Serotypes

Gregorevic, P., Blankenship, M.J., Allen, J. M., Crawford, R.W., Meuse, L., Miller, D.G., Russell, D.W., and Chamberlain, J.S. (2004). Systemic delivery of genes to striated muscles using adeno-associated virus vectors. Nat. Med. 10:828-834. PMC1365046

Halbert, C.L., Rutledge, E.A., Allen, J.M., Russell, D.W., and Miller, A.D.(2000). Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J. Virol.74:1524-32.PMC111488

Inoue, N., and Russell, D.W.(1998).Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectors.J. Virol.72: 7024-7031. PMC109922

Rutledge, E.A., Halbert, C.L., and Russell, D.W. (1998).Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV Type 2.J. Virol. 72:309-319. PMC109378

Halbert, C.L., Standart, T., Aitken, M.L., Alexander, I.E., Russell, D.W., and Miller, A.D. (1997). Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence and readministration. J. Virol.71: 5932-5941. PMC191849

Koeberl, D.D., Alexander, I.E., Halbert, C.L., Russell, D.W., and Miller, A.D. (1997). Persistent expression of human factor IX from mouse liver after intravenous injection of AAV vectors. Proc. Natl. Acad. Sci. USA. 94: 1426-1431. PMC19807

Alexander, I.E., Russell, D.W., and Miller, A.D. (1997). Transfer of contaminants in adeno-associated virus vector stocks can mimic transduction and lead to artifactual results. Hum. Gene Ther.8:1911-1920. PMID: 9382957

Alexander, I.E., Russell, D.W., Spence, A.M., and Miller, A.D.(1996).Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors.Hum. Gene Ther.7: 841-850. PMID: 8860836

Russell, D.W., Alexander, I.E., and Miller, A.D.(1995).DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc. Natl. Acad. Sci. USA 92:5719-5723. PMC41768

Alexander, I.E., Russell, D.W., and Miller, A.D.(1994).DNA-damaging agents greatly increase the transduction of non-dividing cells by adeno-associated virus vectors.J. Virol.68:8282-8287.PMC237296

 

Foamy Virus Vectors

Bauer, T.R., Jr., Tuschong, L.M., Calvo, K.R., Shive, H.R., Burkholder, T.H., Karlsson, E.K., West, R.R., Russell, D.W., and Hickstein, D.D. (2013). Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency. Mol. Ther. 21:964-972. PMCID: PMC3666632

Deyle, D.R., Khan, I.F., Ren, G., and Russell, D.W. (2013). Lack of genotoxicity due to foamy virus vector integration in human iPSCs. Gene Ther. 20:868-873. PMCID: PMC3655141

Bauer, T.R., Olson, E.M., Huo, Y., Tuschong, L.M., Allen, J.M., Li, Y., Burkholder, T.H., and Russell, D.W. (2011). Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter. Gene Ther. 18:553-559. PMC3079787

Ohmine, K., Li, Y., Bauer, T.R., Hickstein, D.D., and Russell, D.W. (2011). Tracking of specific integrant clones in dogs treated with foamy virus vectors. Hum. Gene Ther. 22:217-224. PMC3042306

Deyle, D.R., Li, Y., Olson, E.M., and Russell, D.W. (2010). Non-integrating foamy virus vectors. J. Virol. 84:9341-9349. PMC2937610

Andrianaki, A., Siapati, E.K., Hirata, R.K., Russell, D.W., and Vassilopoulos, G. (2010) Dual transgene expression by foamy virus vectors carrying an endogenous bidirectional promoter. Gene Therapy 17:380-388. PMID: 19907502

Trobridge, G.D., Allen, J.M., Peterson, L., Ironside, C.G., Russell, D.W. and Kiem, H.P. (2009). Foamy and lentiviral vectors transduce canine long-term repopulating cells at similar efficiency. Hum. Gene Ther. 20:519-523. PMC2828621

Bauer, T.R., Allen, J.M., Hai, M., Tuschong, L.M., Khan, I.F., Olson, E.M., Adler, R.L., Burkholder, T.H., Gu, Y., *Russell, D.W., and *Hickstein, D.D. (2008). Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. Nat. Med. 14:93-97(*co-corresponding authors). PMID: 18157138

Taylor, J.A., Vojtech, L., Bahner, I., Kohn, D.B., Von Laer, D., Russell, D.W., and Richard, R.E. (2008). Foamy virus vectors expressing anti-HIV transgenes efficiently block HIV-1 replication.Mol. Ther. 16:46-51. PMID: 17955023

Kiem, H.P., Allen, J., Trobridge, G., Olson, E., Keyser, K., Peterson, L., and Russell, D.W. (2007). Foamy virus-mediated gene transfer to canine repopulating cells. Blood 109:65-70. PMC1785072

Trobridge, G.D., Miller, D.G., Jacobs, M.A., Allen, J.A., Kiem, H.P., Kaul, R., and Russell, D.W. (2006). Foamy virus vector integration sites in normal human cells. Proc. Natl. Acad. Sci. USA 103:1498-1503. PMC1360565

Josephson, N.C., Trobridge, G., and Russell, D.W. (2004). Transduction of long-term and mobilized peripheral blood derived NOD/SCID repopulating cells by foamy virus vectors. Hum. Gene Ther. 15:87-92. PMID: 14965380

Trobridge, G., and Russell, D.W. (2004). Cell cycle requirements for transduction by foamy virus vectors as compared to oncovirus and lentivirus vectors. J. Virol. 78:2327-2335. PMC369213

Trobridge, G., Josephson, N., Vassilopoulos, G., Mac, J, and Russell, D.W. (2002). Improved foamy virus vectors with minimal cis-acting sequences. Mol. Ther. 6:321-328. PMID: 12231167

Josephson, N.C., Vassilopoulos, G., Trobridge, G.D., Priestley, G.V., Wood, B.L., Papayannopoulou, T., and Russell, D.W. (2002). Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors. Proc. Natl. Acad. Sci. USA 99:8295-8300. PMC123061

Trobridge, G.D., Vassilopoulos, G., Josephson, N., and Russell, D.W. (2002). Gene transfer with foamy virus vectors. Methods Enzymol. 346:628-648. PMID: 11883096

Vassilopoulos, G., Trobridge, G., Josephson, N.C., and Russell, D.W. (2001).Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors. Blood 98:604-609. PMID: 11468157

Trobridge, G.D., and Russell, D.W.(1998). Helper-free foamy virus vectors. Hum. Gene Ther. 9:2517-2525.PMC3010407

Hirata, R.K., Miller, A.D., Andrews, R.G., and Russell, D.W.(1996). Transduction of hematopoietic cells by foamy virus vectors.Blood 88: 3654-3661. PMID: 8896436

Russell, D.W., and Miller, A.D.(1996).Foamy virus vectors.J. Virol. 70:217-222. PMC189807

 

Ancient History

Russell, D.W. and Zinder, N.D.(1987).Hemimethylation prevents DNA replication in Escherichia coli.Cell 50:1071-1079. PMID: 3304662

Russell, D.W.(1988). Strand segregation or recombination.Nature 329:678. PMID: 3670372

Russell, D.W., and Hirata, R.K.(1989).The detection of extremely rare DNA modifications.Methylation in dam- and hsd- Escherichia coli strains.J. Biol. Chem. 264:10787-10794. PMID: 2659593

Russell, D.W., and Horiuchi, K.(1991).The mutH gene regulates the replication and methylation of the pMB1 origin.J. Bacteriol. 173: 3209-3214. PMC207916