Stem Cell Engineering
Riolobos, L., Hirata, R.K., Turtle, C.J., Wang, P.R., Gornalusse, G.G., Zavajlevski, M., Riddell, S.R., and Russell, D.W. (2013). HLA engineering of human pluripotent stem cells. Mol. Ther. 21:1232-1241. PMCID: PMC3677304
Li, B.L., Chang, K.H., Wang, P.R., Hirata, R.K., Papayannopoulou, T., and Russell, D.W. (2012). Trisomy correction in Down Syndrome induced pluripotent stem cells. Cell Stem Cell 11:615-619. PMCID: PMC3705773
Deyle, D.R., Khan, I.F., Ren, G., Wang, P.R., Kho, J., Schwarze, U., and Russell, D.W. (2012). Normal collagen and bone production by gene-targeted human Osteogenesis Imperfecta iPSCs. Mol. Ther. 20:204-213.PMID: 22031238
Khan, I.F., Hirata, R.K., Wang, P.R., Li, Y., Kho, J., Nelson, A., Huo, Y., Zavajlevski, M., Ware, C., and Russell, D.W. (2010). Engineering of human pluripotent stem cells by AAV-mediated gene targeting. Mol. Ther. 18:1192-1199. PMC2889726
Lamba, D.A., McUsic, A., Hirata, R.K., Wang, P.R., Russell, D.W. and Reh, T.A. (2010). Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE. 5:e8763. PMC2808350
Chang, K.H., Huang, A., Hirata, R.K., Wang, P.R., Han H., Li, Q., Russell, D.W. and Papayannopoulou, T. (2010). Globin phenotype of erythroid cells derived from human induced pluripotent stem cells. Blood. 115:2553-2554. PMC2845905
Chamberlain, J.R., Deyle, D.R., Schwarze, U., Wang, P., Hirata, R.K., Li, Y., Byers, P.H., and Russell, D.W. (2008).Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta.Mol. Ther. 16:187-193. PMID: 17955022
Gharwan, H., Hirata, R.K., Wang, P., Richard, R.E., Wang, L., Olson, E., Allen, J., Ware, C.B., and Russell, D.W. (2007).Transduction of human embryonic stem cells by foamy virus vectors. Mol. Ther. 15:1827-1833. PMID: 17622243
Chamberlain, J.R., Schwarze, U., Wang, P., Hirata, R.K., Hankenson, K.D., Pace, J.M., Underwood, R.A., Song, K.M., Sussman, M., Byers, P.H., and Russell, D.W. (2004). Gene targeting in stem cells from individuals with osteogenesis imperfecta.Science 303:1198-1201. PMID: 14976317
Vassilopoulos, G., Wang, P., and Russell, D.W. (2003). Transplanted bone marrow regenerates liver by cell fusion. Nature 422:901-904. PMID: 12665833
AAV-Mediated Gene Targeting
Deyle, D.R., Li, L.B., Ren, G., and Russell, D.W. (In press). The effects of polymorphisms on human gene targeting. Nucl. Acids Res. 38:
Wang, P.R., Xu, M., Toffanin, S., Li, Y., Llovett, J.M., and Russell, D.W. (2012). Induction of hepatocellular carcinoma by in vivo gene targeting. Proc. Natl. Acad. Sci. USA.109:11264-11269.
Khan, I.F., Hirata, R.K., and Russell, D.W. (2011). AAV-mediated gene targeting methods for human cells. Nat.Protoc.6:482-501. PMID: 21455185
Cornea, A.M., and Russell, D.W. (2010). Chromosomal position effects on AAV-mediated gene targeting. Nucl. Acids Res.38:3582-3594. PMC2887962
Russell, D.W., and Hirata, R. K. (2008).Human gene targeting favors insertions over deletions. Hum. Gene Ther. 19:907-914. PMC2940567
Fernandez, S.L., Russell, D.W., and Hurlin, P.J. (2007). Development of human gene reporter cell lines using rAAV-mediated homologous recombination.Biol. Proced. Online 9:84-90.PMC2374725
Miller, D.G., Wang, P., Petek, L.M., Hirata, R.K., Sands, M.S., and Russell, D.W. (2006). Gene targeting in vivo by adeno-associated virus vectors. Nat. Biotechnol. 24:1022-1026. PMID: 16878127
Hendrie, P.C., and Russell, D.W. (2005). Gene targeting with viral vectors. Mol. Ther. 12:9-17 PMID: 15932801
Trobridge, G., Hirata, R.K., and Russell, D.W. (2005). Gene targeting by adeno-associated virus vectors is cell-cycle dependent. Hum. Gene Ther. 16:522-526. PMID: 15871683
Hirata, R.H., Xu, C., Dong, R., Miller, D.G., Ferguson, S., and Russell, D.W. (2004). Efficient PRNP gene targeting in bovine fibroblasts by adeno-associated virus vectors.Cloning Stem Cells 6:31-36. PMID: 15107244
Hendrie, P.C., Hirata, R.K, and Russell, D.W. (2003). Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus Minute Virus of Mice. J. Virol. 77:13136-13145. PMC296056
Miller, D.G., Petek, L.M., and Russell, D.W. (2003).Human gene targeting by adeno-associated virus vectors is enhanced by DNA double strand breaks. Mol. Cell. Biol. 23:3550-3557. PMC164770
Hirata, R.K., Chamberlain, J.C., Dong, R., and Russell, D.W. (2002).Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat. Biotechnol. 20:735-738. PMID: 12089561
Russell, D.W., Hirata, R.K., and Inoue, N. (2002). Validation of AAV-mediated gene targeting. Nat. Biotechnol. 20:658.
Inoue, N., Dong, R., Hirata, R. K., and Russell, D.W. (2001). Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors.Mol. Ther. 3:526-530. PMID: 11319913
Hirata, R.K., and Russell, D.W. (2000). Design and packaging of adeno-associated virus gene targeting vectors. J. Virol.74: 4612-4620. PMC11198
Inoue, N., Hirata, R.K., and Russell, D.W.(1999).High-fidelity correction of mutations at multiple chromosomal positions by viral vectors.J. Virol.73:7376-7380. PMC104264
Russell, D.W., and Hirata, R.K.(1998).Human gene targeting by viral vectors.Nat. Genet. 18:325-330. PMC3010411
Vector Integration and Genotoxicity
Deyle, D.R., Khan, I.F., Ren, G., and Russell, D.W.(2013). Lack of genotoxicity due to foamy virus vector integration in human iPSCs. Mol. Ther. 20:868-873. PMCID: PMC3655141
Petek, L.M., Russell, D.W., and Miller, D.G. (2010). Frequent endonuclease cleavage at off-target locations in vivo. Mol. Ther.18:983-986. PMC2890094
Hu, J., Renaud, G., Golmes, T., Ferris, A., Hendrie, P.C., Donahue, R.E., Hughes, S.H., Wolfsberg, T., Russell, D.W., and Dunbar, C.E. (2008). Evidence for reduced genotoxicity for avian leucosis sarcoma virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors. Mol. Ther. 16:1617-1623. PMC2561952
Hendrie, P.C., Huo, Y., Stolitenko, R.B., and Russell D.W. (2008).A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses. Mol. Ther.16:534-540. PMID: 18209733
Russell, D.W.(2007). AAV vectors, insertional mutagenesis and cancer. Mol. Ther. 15:1740-1743. PMID: 17882145
Donsante, A., Miller, D.G., Li, Y., Vogler, C., Brunt, E.M., *Russell, D.W., and *Sands, M.S. (2007).AAV vector integration sites in mouse hepatocellular carcinoma. Science 317:477. (*co-corresponding authors) PMID: 17656716
Miller, D.G., Trobridge, G., Petek, L.M., Jacobs, M.A., Kaul, R., and Russell, D.W. (2005). Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J. Virol.79:11434-11442. PMC1193581
Miller, D.G., Petek, L., and Russell, D.W. (2004). Adeno-associated virus vectors integrate at chromosome breakage sites. Nat. Genet. 36:767-773. PMID: 15208627
Miller, D.G., Rutledge, E.A., and Russell, D.W. (2002). Chromosomal effects of adeno-associated virus vector integration. Nat. Genet. 30:147-148. PMID: 11799395
Rutledge, E.A., and Russell, D.W. (1997).Adeno-associated virus vector integration junctions. J. Virol. 71:8429-8436. PMC192305
AAV Vector Biology and Serotypes
Gregorevic, P., Blankenship, M.J., Allen, J. M., Crawford, R.W., Meuse, L., Miller, D.G., Russell, D.W., and Chamberlain, J.S. (2004). Systemic delivery of genes to striated muscles using adeno-associated virus vectors. Nat. Med. 10:828-834. PMC1365046
Halbert, C.L., Rutledge, E.A., Allen, J.M., Russell, D.W., and Miller, A.D.(2000). Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J. Virol.74:1524-32.PMC111488
Inoue, N., and Russell, D.W.(1998).Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectors.J. Virol.72: 7024-7031. PMC109922
Rutledge, E.A., Halbert, C.L., and Russell, D.W. (1998).Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV Type 2.J. Virol. 72:309-319. PMC109378
Halbert, C.L., Standart, T., Aitken, M.L., Alexander, I.E., Russell, D.W., and Miller, A.D. (1997). Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence and readministration. J. Virol.71: 5932-5941. PMC191849
Koeberl, D.D., Alexander, I.E., Halbert, C.L., Russell, D.W., and Miller, A.D. (1997). Persistent expression of human factor IX from mouse liver after intravenous injection of AAV vectors. Proc. Natl. Acad. Sci. USA. 94: 1426-1431. PMC19807
Alexander, I.E., Russell, D.W., and Miller, A.D. (1997). Transfer of contaminants in adeno-associated virus vector stocks can mimic transduction and lead to artifactual results. Hum. Gene Ther.8:1911-1920. PMID: 9382957
Alexander, I.E., Russell, D.W., Spence, A.M., and Miller, A.D.(1996).Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors.Hum. Gene Ther.7: 841-850. PMID: 8860836
Russell, D.W., Alexander, I.E., and Miller, A.D.(1995).DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc. Natl. Acad. Sci. USA 92:5719-5723. PMC41768
Alexander, I.E., Russell, D.W., and Miller, A.D.(1994).DNA-damaging agents greatly increase the transduction of non-dividing cells by adeno-associated virus vectors.J. Virol.68:8282-8287.PMC237296
Foamy Virus Vectors
Bauer, T.R., Jr., Tuschong, L.M., Calvo, K.R., Shive, H.R., Burkholder, T.H., Karlsson, E.K., West, R.R., Russell, D.W., and Hickstein, D.D. (2013). Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency. Mol. Ther. 21:964-972. PMCID: PMC3666632
Deyle, D.R., Khan, I.F., Ren, G., and Russell, D.W. (2013). Lack of genotoxicity due to foamy virus vector integration in human iPSCs. Gene Ther. 20:868-873. PMCID: PMC3655141
Bauer, T.R., Olson, E.M., Huo, Y., Tuschong, L.M., Allen, J.M., Li, Y., Burkholder, T.H., and Russell, D.W. (2011). Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter. Gene Ther. 18:553-559. PMC3079787
Ohmine, K., Li, Y., Bauer, T.R., Hickstein, D.D., and Russell, D.W. (2011). Tracking of specific integrant clones in dogs treated with foamy virus vectors. Hum. Gene Ther. 22:217-224. PMC3042306
Deyle, D.R., Li, Y., Olson, E.M., and Russell, D.W. (2010). Non-integrating foamy virus vectors. J. Virol. 84:9341-9349. PMC2937610
Andrianaki, A., Siapati, E.K., Hirata, R.K., Russell, D.W., and Vassilopoulos, G. (2010) Dual transgene expression by foamy virus vectors carrying an endogenous bidirectional promoter. Gene Therapy 17:380-388. PMID: 19907502
Trobridge, G.D., Allen, J.M., Peterson, L., Ironside, C.G., Russell, D.W. and Kiem, H.P. (2009). Foamy and lentiviral vectors transduce canine long-term repopulating cells at similar efficiency. Hum. Gene Ther. 20:519-523. PMC2828621
Bauer, T.R., Allen, J.M., Hai, M., Tuschong, L.M., Khan, I.F., Olson, E.M., Adler, R.L., Burkholder, T.H., Gu, Y., *Russell, D.W., and *Hickstein, D.D. (2008). Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. Nat. Med. 14:93-97(*co-corresponding authors). PMID: 18157138
Taylor, J.A., Vojtech, L., Bahner, I., Kohn, D.B., Von Laer, D., Russell, D.W., and Richard, R.E. (2008). Foamy virus vectors expressing anti-HIV transgenes efficiently block HIV-1 replication.Mol. Ther. 16:46-51. PMID: 17955023
Kiem, H.P., Allen, J., Trobridge, G., Olson, E., Keyser, K., Peterson, L., and Russell, D.W. (2007). Foamy virus-mediated gene transfer to canine repopulating cells. Blood 109:65-70. PMC1785072
Trobridge, G.D., Miller, D.G., Jacobs, M.A., Allen, J.A., Kiem, H.P., Kaul, R., and Russell, D.W. (2006). Foamy virus vector integration sites in normal human cells. Proc. Natl. Acad. Sci. USA 103:1498-1503. PMC1360565
Josephson, N.C., Trobridge, G., and Russell, D.W. (2004). Transduction of long-term and mobilized peripheral blood derived NOD/SCID repopulating cells by foamy virus vectors. Hum. Gene Ther. 15:87-92. PMID: 14965380
Trobridge, G., and Russell, D.W. (2004). Cell cycle requirements for transduction by foamy virus vectors as compared to oncovirus and lentivirus vectors. J. Virol. 78:2327-2335. PMC369213
Trobridge, G., Josephson, N., Vassilopoulos, G., Mac, J, and Russell, D.W. (2002). Improved foamy virus vectors with minimal cis-acting sequences. Mol. Ther. 6:321-328. PMID: 12231167
Josephson, N.C., Vassilopoulos, G., Trobridge, G.D., Priestley, G.V., Wood, B.L., Papayannopoulou, T., and Russell, D.W. (2002). Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors. Proc. Natl. Acad. Sci. USA 99:8295-8300. PMC123061
Trobridge, G.D., Vassilopoulos, G., Josephson, N., and Russell, D.W. (2002). Gene transfer with foamy virus vectors. Methods Enzymol. 346:628-648. PMID: 11883096
Vassilopoulos, G., Trobridge, G., Josephson, N.C., and Russell, D.W. (2001).Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors. Blood 98:604-609. PMID: 11468157
Trobridge, G.D., and Russell, D.W.(1998). Helper-free foamy virus vectors. Hum. Gene Ther. 9:2517-2525.PMC3010407
Hirata, R.K., Miller, A.D., Andrews, R.G., and Russell, D.W.(1996). Transduction of hematopoietic cells by foamy virus vectors.Blood 88: 3654-3661. PMID: 8896436
Russell, D.W., and Miller, A.D.(1996).Foamy virus vectors.J. Virol. 70:217-222. PMC189807
Ancient History
Russell, D.W. and Zinder, N.D.(1987).Hemimethylation prevents DNA replication in Escherichia coli.Cell 50:1071-1079. PMID: 3304662
Russell, D.W.(1988). Strand segregation or recombination.Nature 329:678. PMID: 3670372
Russell, D.W., and Hirata, R.K.(1989).The detection of extremely rare DNA modifications.Methylation in dam- and hsd- Escherichia coli strains.J. Biol. Chem. 264:10787-10794. PMID: 2659593
Russell, D.W., and Horiuchi, K.(1991).The mutH gene regulates the replication and methylation of the pMB1 origin.J. Bacteriol. 173: 3209-3214. PMC207916
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