Project 2
Project 2: BCRP in pregnancy: substrate specificity, expression, and regulation.
PI: Qingcheng Mao, Ph.D.
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Co-PI: Jashvant Unadkat, Ph.D.
The Breast Cancer Resistance Protein (BCRP/ABCG2) appears to transport drugs that are similar or the same as that transported by P-glycoprotein. BCRP is highly expressed in the intestine, placenta, and liver; thus BCRP is likely important in determining absorption, distribution (including into or out of the fetal compartment), and elimination of drugs routinely administered to pregnant women.
- The purpose of the BCRP project is to:
- Further characterize which drugs routinely administered to pregnant women are transported by BCRP.
- Determine if BCRP expression is affected by pregnancy and investigate the mechanisms by which this happens.
- Examine the role of BCRP in the pharmacokinetics of BCRP transported drugs that are routinely administered to pregnant women.
- Knowledge gained from such studies will aid in understanding the mechanisms by which maternal and fetal exposure to drugs is altered during pregnancy.