Publications

Unadkat JD, Dahlin A, Vijay S. Placental drug transporters. Curr Drug Metab 2004; 5:125-31.
Wade NA, Unadkat JD, Huang S, Shapiro DE, Mathias A, Yasin S, Ciupak G, Watts DH, Delke I, Rathore M, Hitti J, Frenkel L, Samelson R, Smith ME, Mofenson L, and Burchett SK. Pharmacokinetics and safety of stavudine in HIV-infected pregnant women and their infants: Pediatric AIDS clinical trials group protocol 332. J Infect Dis 2004; 190:2167–2174.
Unadkat JD, Wara DW, Huang S, Mathias AA, Holland DT, Connor J, Hughes M, Paul ME, Nguyen B-Y, Watts DH, Mofenson LM, Smith E, and Tuomala R. Pharmacokinetics and safety of Indinavir in HIV-infected pregnant women: a PACTG 358 study. Clinical Pharmacology and Therapeutics, Submitted, 2006.
Wu X, Wang H, Mao Q, and Unadkat JD. Time course of increase in hepatic CYP3a activity and expression during pregnancy. Abstract, 13th ISSX and 20th JSSX meeting, Maui, Hawaii, 2005.
Kirby B and Unadkat JD. A sensitive HPLC-MS method for determination of digoxin in biological fluids of pregnant women. In Preparation, 2006.
Mathias A, Maggio-Price L, Gupta A, and Unadkat JD. Changes in pharmacokinetics of anti-HIV protease inhibitors during pregnancy: the role of CYP3a and P-glycoprotein. J Pharmacol Exp Ther 2005 Nov 17; [epub ahead of print]

Gupta A, Zhang Y, Unadkat JD, and Mao Q. HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther 2004; 310: 334-341.
Mao, Q and Unadkat, JD. Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport. AAPS J 2005; 7(1): E118-33.
Mathias AA, Hitti J, and Unadkat JD. P-glycoprotein and Breast Cancer Resistance Protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol 2005; 289(4): R963-9.
Zhang Y, Gupta A, Wang H, Zhou L, Vethanayagam RR, Unadkat JD, and Mao Q. BCRP Transports Dipyridamole And Is Inhibited By Calcium Channel Blockers. Pharm Res 2005 Dec; 22 (12);2023-34.
Wang H, Unadkat JD and Mao Q. Regulation of BCRP expression by progesterone and 17β-estradiol. 2004 AAPS Annual Meeting and Exposition, Baltimore, MD
Wang H, Zhou L, Gupta A, Vethanayagam RR, Zhang Y, Unadkat JD and Mao Q. Regulation of BCRP/ABCG2 Expression By Progesterone and 17β-Estradiol in Human Placental BeWo Cells. Am J Physiol Endocrinol Metab 2005 Dec 13; [epub ahead of print]
Gupta A, Dai Y, Vethanayagam RR, Hebert MF, Thummel KE, Unadkat JD, Ross RR, and Mao Q. Cyclosporin A, Tacrolimus and Sirolimus Are Potent Inhibitors of the Human Breast Cancer Resistance Protein (ABCG2) and Reverse Resistance to Mitoxantrone and Topotecan. Cancer Chemother Pharmacol 2006 Jan 11; 1-10 [epub ahead of print]

Ganapathy V, Fei YJ, and Prasad PD, Heterologous expression systems for studying placental transporters In: Methods in Molecular Medicine, Vol. 122: Placenta and Trophoblast: Methods and Protocols (Soares, M. J., and Hunt,, J. S., eds), Vol. B: pp. 285-300. Humana Press.
Ganapathy V and Prasad PD. Role of transporters in placental transfer of drugs. Toxicology and Applied Pharmacology, 207 (Suppl. 1): 381-387, 2005.
Umapathy SN, Zhuang L, Prasad PD, Subramanian R, and Ganapathy V. Expression of OCTN1 in placental brush border membrane and its interaction with antidepressants. J Pharmacol. Exp. Ther. 2005; submitted.
Itagaki S, Zhuang L, Prasad PD, and Ganapathy V. Interaction of human OCT3 with antidepressants. In Preparation
Prasad PD, Shetty S, and Ganapathy V. Differential expression of genes in placentas from control mice and Tat-transgenic mice. In Preparation
Gupta N, Martin PM, Miyauchi S, Hu H, Martindale RG, Podolsky R, and Ganapathy V. Downregulation of BCRP/ABCG2 in cancer. Biochemical Journal 2005; Submitted.