regulated cell therapy
Papers
Blau CA, Peterson KR, Drachman JG and Spencer DM. A proliferation switch for genetically modified cells. Proceedings of the National Academy of Sciences USA 94:3076-3081, 1997.
Jin L, Asano H and Blau CA. Stimulating cell proliferation through the pharmacologic activation of c-kit. Blood 91:890-897, 1998.
Jin L, Siritanaraktul N, Emery DW, Richard RE, Kaushansky K, Papayannopoulou Th and Blau CA. Targeted expansion of genetically modified bone marrow cells. Proceedings of the National Academy of Sciences USA 95:8093-8097, 1998.
Jin L, Neff T and Blau CA. Marrow sensitization to 5 fluorouracil using the ligands for flt-3 and c-kit. Experimental Hematology 27:520-525, 1999.
Richard RE, Wood B, Zeng H, Papayannopoulou Th and Blau CA. Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization. Blood 95:430-6, 2000.
Jin L, Zeng H, Otto KG, Richard RE, Emery DW and Blau CA. In vivo selection using a cell growth switch. Nature Genetics 26:64-66, 2000.
Otto KG, Jin L, Spencer DM and Blau CA. Cell Proliferation Induced by Forced Engagement of c-Kit and Flt-3. Blood 97:3662-3664, 2001.
Zeng H, Masuko M, Jin L, Neff T, Otto KG and Blau CA. Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells. Blood 98:328-334, 2001.
Otto KG, Broudy VC, Lin N, Parganas E, Drachman JG, Luthi JN, Ihle JN and Blau CA. Membrane localization is not required for mpl function in normal hematopoietic cells. Blood 98:2077-2083, 2001.
Whitney ML, Otto K, Blau CA, Reinecke H and Murry CE. Control of myoblast proliferation with a synthetic ligand. Journal of Biological Chemistry 276:41191-41196, 2001.
Ieremia J and Blau CA. Limitations of a mouse model of sickle cell anemia. Blood Cells, Molecules & Diseases 28:146-151, 2002.
Li Z-Y, Otto KG, Richard RE, Ni S, Kirillova, I, Fausto, N, Blau CA and Lieber, A. Dimerizer-induced proliferation of genetically modified hepatocytes. Molecular Therapy 5:420-6, 2002.
Zhao S, Zoller K, Masuko M, Rojnuckarin P, Yang X, Parganas E, Kaushansky K, Ihle JN, Papayannopoulou Th, Willerford DM, Clackson T and Blau CA. JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO Journal 21:2159-2167, 2002.
Neff T, Horn PA, Valli VE, Gown AM, Wardwell S, Wood BL, von Kalle C, Schmidt M, Peterson LJ, Morris JC, Richard RE, Clackson T, Kiem HP, Blau CA. Pharmacologically regulated in vivo selection in a large animal. Blood 100: 2026-2031, 2002.
Richard RE and Blau CA. Selective expansion of genetically modified cord blood cells. Stem Cells 21: 71-78, 2003.
Berger C, Blau CA, Huang M-L, Iuliucci JD, Dalgarno DC, Gaschet J, Heimfeld S, Clackson T, Riddell SR. Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model. Blood 103:1261-9, 2004.
Richard RE, Weinreich M, Chang K-H, Ieremia J, Stevenson MM, Blau CA. Modulating erythrocyte mixed chimerism in a mouse model of pyruvate kinase deficiency. Blood 103:4432-4439, 2004.
Zhao S, Weinreich M, Blau CA. In vivo selection using a JAK2-based cell growth switch. Molecular Therapy 10:456-458, 2004.
Richard RE, DeClaro A, Yan J, Chien S, Kiem HP, Clackson T, Andrews R, and Blau CA. Heterogeneity among large animal models of in vivo selection. Molecular Therapy 10:730-740, 2004.
Emery DW, Tubb J, Nishino Y, Nishino T, Otto KG, Stamatoyannopoulos G, and Blau CA. Selection with a regulated cell growth switch increases the likelihood of expression for a linked γ-globin gene in vitro and in vivo. Blood Cells, Molecules & Diseases 34:235-47. 2005.
Gandi M, Ihara K, Cummings C, Pendergrass T, Blau CA and Drachman JD. Congenital Megakaryocytic Thrombocytopenia in Three Siblings: Molecular Analysis of Atypical Clinical Presentation. Experimental Hematology 33:1215-21, 2005.
Blau CA, Yan J, Neades R, Navas PA, Peterson KR. g-globin gene expression in CID-dependent multi-potential cells established from b-YAC transgenic mice. Journal of Biological Chemistry 280:36642-7, 2005.
Richard RE, Siritanaratkul N, Jonlin E, Skarpidi E, Heimfeld S, Blau CA. Collection of blood stem cells from patients with sickle cell anemia. Blood Cells Mol Dis 35:384-8, 2005.
Nagasawa Y, Wood B, Wang L, Lintmaer I, Guo W, Papayannopoulou Th, Harkey M, Nourigat C, Blau CA. Anatomical Compartments Modulate the Response of Human Hematopoietic Cells to a Mitogenic Signal In Vitro and In Vivo. Stem Cells 24:908-17, 2006.
Weinreich MA, Lintmaer I, Wang L, Liggitt D, Harkey M, Blau CA. Growth Factor Receptors as Regulators of Hematopoiesis. Blood 108:3713-21, 2006.
Miller CA, Blau CA. Using Gene Transfer to Circumvent Off-Target Effects. (2008) Gene Therapy 15:759-64.
Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Kiem HP, Blau CA. Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs. Mol Ther. 2011 Feb 15.