Project 1: Optimization to improve the protective capacity of the Tp0751 Syphilis vaccine candidate

Summary

This project expands upon prior partial protection results using the Tp0751 vascular adhesin with the goal of developing an enhanced vaccinogen that protects against disseminated T. pallidum infection. In this project we are determining the protective region(s) of the Tp0751 immunogen, optimizing the Tp0751 vaccinogen formulation and delivery, and testing the heterologous protective capacity and duration of achieved protection.