Publications
- 213. L. Wu, Y.L. Qin, T. Schneider, G. Yen, J. Wang, S. Xu, M. Li, A. Paguirigan, J. Smith, J. Radich, R. Anand, D.T. Chiu (2018) "Self-Digitization Dielectrophoretic (SD-DEP) Chip for High Efficiency Single-Cell Capture, On-Demand Compartmentalization, and Downstream Nucleic-Acid Analysis" Angew. Chem. Int. Ed. (in press)
- 212. R. Jauregui, S. Srinivasan, L.N. Vojtech, H.S. Gammill, D.T. Chiu, F. Hladik, P.S. Stayton, J.J. Lai (2018) "Temperature-responsive magnetic nanoparticles for enabling affinity separation of extracellular vesicles" ACS Appl. Mater. Interfaces (in press).
- 211. H. Chen, X. Fang, Y. Jin, X. Hu, M. Yin, X. Men, N. Chen, C. Fan, D.T. Chiu, Y. Wan, C. Wu (2018) "Semiconducting polymer nanocavities: porogenic synthesis, tunable host-guest interactions, and efficient drug/siRNA delivery" Small (in press).
- 210. L.A. Andronico, M. Mirasoli, M. Guardigli, A. Quintavalla, M. Lombardo, C. Trombini, D.T. Chiu, A. Roda (2018) "Thermochemiluminescent semiconducting polymer dots as sensitive nanoprobe for reagentless immunoassay" Nanoscale (in press).
- 209. K. Sun, Y. Yang, H. Zhou, Y. Yuan, S. Yin, W. Qin, J. Yu, D.T. Chiu, Z. Yuan, X. Zhang, C. Wu (2018) "Wireless glucose monitoring via smartphone using ultrasensitive polymer-dot transducer" ACS Nano (in press).
- 208. D. Chen, Y. Yuan, J. Yu, D.T. Chiu, C. Wu (2018) "Purification of semiconducting polymer dots via gel filtration prior to cytotoxicity assay and stem cell labeling" Anal. Chem. 90, 5569-5575.
- 207. A.M. Thompson, J.L. Smith, L.D. Monroe, J.E. Kreutz, T. Schneider, B.S. Fujimoto, D.T. Chiu, J.P. Radich, A.L. Paguirigan (2018) "Self-digitization chip for single-cell genotyping of cancer-related mutations" PLoS ONE 13, e0196801.
- 206. S.R. Jung, R. Han, W. Sun, B.S. Fujimoto, J. Yu, C.T. Kuo, Y. Rong, X.H. Zhou, D.T. Chiu (2018) "A single-molecule flow platform for the quantification of biomolecules attached to single nanoparticles" Anal. Chem. 90, 6089-6095.
- 205. X. Wu, Q. DeGottardi, I. Wu, J. Yu, L. Wu, F. Ye, C.T. Kuo, W.W. Kwok, D.T. Chiu (2017) "Lanthanide-containing semiconducting polymer dots that function for both flow cytometry and mass cytometry" Angew. Chem. Int. Ed. 56, 14908-14912.
- 204. L. Chen, L. Wu, J. Yu, C.T. Kuo, T. Jian, I. Wu, Y. Rong, D.T. Chiu (2017) "A highly photostable wide-dynamic range pH sensitive semiconducting polymer dot enabled by dendronizing the near-IR emitters" Chem. Sci. 8, 7236-7245.
- 203. L. Wu, I. Wu, C.C. DuFort, M.A. Carlson, X. Wu, L. Chen, C.T. Kuo, Y. Qing, J. Yu, S.R. Hingorani, D.T. Chiu (2017) "A photostable ratiometric Pdot probe for in vitro and in vivo imaging of hypochlorous acid" J. Amer. Chem. Soc. DOI: 10.1021/jacs.7b01545.
- 202. D. Chen, I. Wu, Z. Liu, Y. Tang, J. Yu, C. Wu, D.T. Chiu (2017) "Semiconducting polymer dots with bright narrow-band emission at 800 nm for biological applications" Chem. Sci. 8, 3390-3398.
- 201.. C.T Kuo, H.S Peng, Y. Rong, J. Yu, W. Sun, B.S. Fujimoto, D.T. Chiu (2017) "Optically encoded semiconducting polymer dots with single-wavelength excitation for barcoding and tracking tumor cells" Anal. Chem. DOI: 10.1021/acs.analchem.7b01214
- 200. X. Wu, D.T. Chiu (2017) " Conjugated polymer nanoparticles and semiconducting polymer dots for molecular sensing and in vivo and cellular Imaging" Conjugated Polymers for Biological and Biomedical Applications 59-85.
- 199. D.T. Chiu; A. deMello; D. Di Carlo; P. Doyle; C. Hansen; R. Maceiczyk; R. Wootton (2017) "Microfluidics: Small but perfectly formed? - successes, challenges & opportunities for microfluidics in the chemical & biological sciences" Chem 2, 201-223.
- 198. S.R. Jung, B.S. Fujimoto, D.T. Chiu (2017) "Quantitative microscopy based on single-molecule fluorescence" Curr. Opin. Chem. Biol. 39, 64-73.
- 197. J. Yu, Y. Rong, C.T. Kuo, X.H. Zhou, D. T. Chiu (2017) "Recent advances in the development of highly luminescent semiconducting polymer dots and nanoparticles for biological imaging and medicine" Anal. Chem. 89, 42-56.
- 196. K. Sun, S. Li, Q. Li, Y. Tang, W. Qin, J. Yu, D.T. Chiu, Z. Yuan, X. Zhang, C. Wu (2016) "Enzyme-conjugated semiconducting polymer dots for long-term optical and in vivo glucose monitoring" ACS Nano 10, 6769-6781.
- 195. X. Wu, L. Wu, I. Wu, D.T. Chiu (2016) "Copper (II)-doped semiconducting polymer dots for nitroxyl imaging in live cells" RSC Adv. 6, 103618-103621.
- 194. C.T. Kuo, A.M. Thompson, M.E. Gallina, F. Ye, E.S. Johnson, W. Sun, M. Zhao, J. Yu, I. Wu, B. Fujimoto, C.C. DuFort, M.A. Carlson, S.R. Hingorani, A.L. Paguirigan, J.P. Radich, D.T. Chiu (2016) "Optical painting and fluorescence activated sorting of single adherent cells labelled with photoswitchable Pdots" Nature Comm. DOI:10.1038/ncomms11468.
- 193. G.S. Yen, J.S. Edgar, S.H. Yoon, Y. Huang, S.R. Heron, D.T. Chiu, D.R. Goodlett (2016) " Polydimethylsiloxane microchannel coupled to surface acoustic wave nebulization mass spectrometry" Rapid Comm. Mass Spec. 30, 1096-1100.
- 192. E.S. Johnson, R.K. Anand, D.T. Chiu (2015)
"Improving detection of circulating tumor cells with low numbers of the targeted surface antigen by ensemble decision aliquot ranking (eDAR)" Anal. Chem. 87, 9389-9395.
- 191. M. Zhao, B. Wei, W.C. Nelson, D.T. Chiu (2015)
"Simultaneous and selective isolation of multiple subpopulations of rare cells from peripheral blood using ensemble-decision aliquot ranking" Lab Chip 15, 3391-3396.
- 190. F. Ye, C.C. White, Y. Jin, X. Hu, S. Hayden, X. Gao, T.J.
Kavanagh, D.T. Chiu (2015) "Toxicity and oxidative stress induced by
semiconducting polymer dots in RAW264.7 mouse macrophages" Nanoscale 7, 10085-10093.
- 189. C. Fang, K. Wang, Z.R. Stephen, Q. Mu, F.M. Kievit, D.T. Chiu,
O.W. Press, M. Zhang (2015) "Temozolomide nanoparticles for targeted
glioblastoma therapy" ACS Appl. Mater. Interfaces 7, 6674-6682.
- 188. Y. Zhang, F. Ye, W. Sun, J. Yu, I. Wu, Y. Rong, Y. Zhang, D.T.
Chiu (2015) "Light-induced crosslinkable semiconducting polymer dots" Chem.
Sci. 6, 2102-2109.
- 187. R.K. Anand, E.S. Johnson, D.T. Chiu (2015) " Negative
dielectrophoretic capture and repulsion of single cells at a bipolar
electrode: the impact of faradaic ion en-richment and depletion" J. Amer.
Chem. Soc. 137, 776-783.
- 186. I. Wu, J. Yu, F. Ye, Y. Rong, C. Wu, M.E. Gallina, Y. Zhang,
Y.H. Chan, W. Sun, D.T. Chiu (2015) " Squaraine based polymer dots with
narrow, bright near-infrared fluorescence for biological applications" J.
Amer. Chem. Soc. 137, 173-178.
- 185. F. Ye, W. Sun, Y. Zhang, C. Wu, J. Yu, X. Zhang, Y. Rong, M.
Zhang, D.T. Chiu (2015) "Single-chain semiconducting polymer dots"
Langmuir 31, 499-505.
- 184. F. Ye, P.B. Smith, D.T. Chiu (2015) " Ultrasensitive protein
detection on dot blots and Western blots with semiconducting polymer dots"
Meth. in Mol. Bio. 1314.
- 183. H.S. Peng and D.T. Chiu (2015) "Soft fluorescent nanomaterials
for biological and biomedical imaging" Chem. Soc. Rev. 44, 4699-4722.
- 182. A.M. Thompson, A. Gansen, A.L. Paguirigan, J.E. Kreutz, J.P.
Radich, D.T. Chiu (2014) "The self-digitization microfluidic chip for the
absolute quantification of mRNA in single cells" Anal. Chem. 86, 12308-12314.
- 181. Y. Rong, J. Yu, X. Zhang, W. Sun, F. Ye, I. Wu, Y. Zhang, S.
Hayden, Y. Zhang, C. Wu and D.T. Chiu (2014) "New yellow fluorescent
semiconducting polymer dots with high brightness, small size and narrow
emission for biological applications" ACS Macro Lett. 3, 1051-1054.
- 180. K. Chang, Z. Liu, H. Chen, L. Sheng, S.X. Zhang, D. T. Chiu,
S. Yin, C. Wu, W. Qin (2014) "Conjugated polymer dots for ultra-stable
full-color fluorescence patterning" Small 10, 4270-4275.
- 179. M. Zhao, P.G. Schiro, D.T. Chiu (2014) "Ensemble-decision aliquot ranking (eDAR) for CTC isolation and analysis" Circulating Tumor Cells: Isolation and Analysis 53-83.
- 178. Q. Li, J. Zhang, W. Sun, J. Yu, C. Wu, W. Qin, D.T. Chiu
(2014) "Europium-complex-grafted polymer dots for amplified quenching and
cellular imaging applications" Langmuir 30, 8607-8614.
- 177. D. Liu, B. Hakimi, M. Volny, J. Rolfs, R.K. Perdue, F.
Turecek, D.T. Chiu (2014) "Modulating patterns of two-phase flow with electric
fields" Biomicrofluidics 8, 044106.
- 176. F. Ye, C. Wu, W. Sun, J. Yu, X. Zhang, Y. Rong, I. Wu, Y.
Zhang, D.T. Chiu (2014) "Semiconducting polymer dots with monofunctional
groups" Chem. Comm. 50, 5604-5607.
- 175. A.M. Thompson, A.L. Paguirigan, J.E. Kreutz, J.P. Radich, D.T.
Chiu (2014) "Microfluidics for single-cell genetic analysis" Lab Chip 14, 3135-3142.
- 174. M. Volny, J. Rolfs, B. Hakimi, P. Frycak, T. Schneider, D.
Liu, G. Yen, D.T. Chiu, F. Turecek (2014) "Nanoliter segmented-flow sampling
mass spectrometry with on-line compartmentalization" Anal. Chem. 86, 3647-3652.
- 173. T. Schneider, G.S. Yen, A.M. Herrick, D.R. Burham, D.T. Chiu
(2013) "Self-digitization of samples into a high-density bottom-well array"
Anal. Chem. 85, 10417-10423.
- 172. Q. Li, K. Sun, K. Chang, D.T. Chiu, C. Wu, W. Qin (2013)
"Ratiometric luminescent detection of an anthrax biomarker with terbium
chelated semiconducting polymer dots" Anal. Chem. 85, 9087-9091.
- 171. M. Zhao, W.C. Nelson, B. Wei, P.G. Schiro, B.M. Hakimi, E.S.
Johnson, R.K. Perdue, G. Gyurkey, L.M. White, S. Whiting, D.T. Chiu (2013)
"New generation of ensemble-decision aliquot ranking based on simplified
microfluidic components for large-capacity trapping of circulating tumor
cells" Anal. Chem. 85, 9671-9677.
- 170. W. Sun, J. Yu, F. Ye, Y. Rong, D.T. Chiu (2013) "Highly
fluorescent semiconducting polymer dots for single-molecule imaging and
sensing" Proc. SPIE-Int. Soc. Opt. Eng. 8812, 881205, 1-9.
- 169. W. Sun, J. Yu, R. Deng, Y. Rong, B. Fujimoto, H. Zhang, D.T.
Chiu (2013) "Highly bright semiconducting polymer dots with ultra-narrow
emission and long luminescence lifetime for time-gated cellular targeting"
Angew. Chem. Int. Ed. 52, 11294-11297.
- 168. D. Liu, B. Hakimi, M. Volny, J. Rolfs, X. Chen, F. Turecek,
D.T. Chiu (2013) "Controlled generation of double emulsions in air" Anal.
Chem. 85, 6190-6194.
- 167. M. Zhao, B. Wei, D.T. Chiu (2013) "Imaging multiple biomarkers
in eDAR captured rare cells with sequential immunostaining and photobleaching"
Methods 64, 108-113.
- 166. Y. Zhang, J. Yu, M.E. Gallina, W. Sun, Y. Rong, D.T. Chiu
(2013) "Highly fluorescent fluorinated semiconducting polymer dots for
cellular imaging and analysis" Chem. Comm. 49, 8256-8258.
- 165. M.Zeigler, W. Sun, Y. Rong, D.T.Chiu (2013) "Hybrid
semiconducting polymer nanoparticles as polarization-sensitive fluorescent
probes" J. Amer. Chem. Soc. 135, 11453-11456.
- 164. J.M. Schurr, B.S. Fujimoto, L. Huynh, D.T. Chiu (2013) "A
theory of molecular chemotaxis" J. of Phys. Chem. B 117,
7626-7652.
- 163. W. Sun, F. Ye, M.E. Gallina, C. Wu, D.T. Chiu (2013)
"Lyophilization of semiconducting polymer dot bioconjugates" Anal.
Chem. 85, 4316-4320.
- 162. F. Ye, P.B. Smith, C. Wu, D.T. Chiu (2013) "Ultrasensitive
detection of proteins on Western blots with semiconducting polymer dots"
Macromol. Rapid Commun. 34, 785-790.
- 161. T. Schneider, J. Kreutz, D.T. Chiu (2013) "The potential
impact of droplet microfluidics in biology" Anal. Chem. 85,
3476-3482.
- 160. B. Neupane, F. Chen, W. Sun, D.T. Chiu, G. Wang (2013) "Tuning
Donut Profile for Spatial Resolution in Stimulated Emission Depletion
Microscopy" Rev. Sci. Instr. 84, 043701.
- 159. X. Zhang, J. Yu, Y. Rong, F. Ye, D.T. Chiu, K. Uvdal (2013)
"High-intensity Near-IR Fluorescence in Semiconducting Polymer Dots Achieved
by Cascade Energy Transfer" Chem. Sci. 4, 2143-2151.
- 158. M. Zhao, P.G. Schiro, J.S. Kuo, K.M. Koehler, D.E. Sabath, V.
Popov, Q. Feng, D.T. Chiu (2013) "An Automated High-Throughput Counting Method
for Screening Circulating Tumor Cells in Peripheral Blood" Anal. Chem.
85, 2465-2471.
- 157. Y. Rong, C. Wu, J. Yu, X. Zhang, F. Ye, M. Zeigler, M.
Gallina, I. Wu, Y. Zhang, Y.H. Chan, W. Sun, K. Uvdal, D.T. Chiu (2013)
"Multicolor fluorescent semiconducting polymer dots with narrow band
emissions" ACS Nano 7, 376-384.
- 156. M.B. Zeigler, D.T. Chiu (2013) "Single-cell nanosurgery"
Methods Mol.Bio. 991,139-148.
- 155. A.E. Sgro, S.M. Bajjalieh, D.T. Chiu (2013) "Single-organelle
analysis of axonal transport vesicles reveals new protein-motor associations"
ACS Chem. Neurosci. 4, 277-284.
- 154. C. Wu and D.T. Chiu (2013) "Semiconducting polymer dots: A new
family of fluorescent nanoparticles for biological applications Angew. Chem.
Int. Ed. 52, 3086-3109.
- 153. J.C. Gadd, B.S. Fujimoto, S.M. Bajjalieh, D.T. Chiu (2012)
"Single-molecule fluorescence quantification with a photobleached internal
standard" Anal. Chem. 84, 10522-10525.
- 152. Y.H. Chan, M.E. Gallina, X. Zhang, I. Wu, Y. Jin, W. Sun, D.T.
Chiu (2012) "Reversible photoswitching of spiropyran conjugated semiconducting
polymer dots" Anal. Chem. 84, 9431-9438.
- 151. W. Sun, S. Hayden, Y. Jin, Y. Rong, J. Yu, F. Ye, Y.H. Chan,
M. Zeigler, C. Wu, D.T. Chiu (2012) "A versatile method for generating
semiconducting polymer dot nanocomposites" Nanoscale 4, 7246-7249.
- 150. R.K. Anand and D.T. Chiu (2012) "Analytical tools for
characterizing heterogeneity in organelle content Curr. Opin. Chem.
Biol. 16, 391-399.
- 149. P.G. Schiro, J.C. Gadd, G.S. Yen, D.T. Chiu (2012) "A
high-throughput fluorescence activated nanoscale subcellular sorter with
single-molecule sensitivity" J. of Phys. Chem. B 116, 10490-10495.
- 148. J. Yu, C. Wu, X. Zhang, F. Ye, M.E. Gallina, Y. Rong, I. Wu,
W. Sun, Y.H. Chan, D.T. Chiu (2012) "Stable functionalization of small
semiconducting polymer dots via covalent cross-linking and their application
for specific cellular imaging" Adv. Mater. 24, 3498-3504.
- 147. X. Zhang, J. Yu, C. Wu, Y. Jin, F. Ye, D.T. Chiu (2012)
"Importance of low-density functionalization for high-performance
semiconducting polymer dots" ACS Nano 6, 5429-5439.
- 146. Y.H. Chan, F. Ye, M.E. Gallina, X. Zhang, Y. Jin, I. Wu, D.T.
Chiu (2012) "Hybrid semiconducting polymer dot-quantum dot with narrow-band
emission, near-infrared fluorescence, and high brightness" J. Amer. Chem.
Soc. 134, 7309-7312.
- 145. A. Gansen, I.K. Dimov, L.P. Lee, D.T. Chiu (2012) "Digital
LAMP in a sample self-digitization chip" Lab Chip 12, 2247-2254.
- 144. Y. Jin, F. Ye, C. Wu, Y.H. Chan, D.T. Chiu (2012) "Generation
of robust functionalized semiconducting polymer dots with polyelectrolytes"
Chem. Comm. 48, 3161-3163.
- 143. J.C. Gadd, K.L. Budzinski, Y.H. Chan, F. Ye, D. T. Chiu (2012)
"Probing the interior of synaptic vesicles with internalized nanoparticles"
Proc. SPIE-Int. Soc. Opt. Eng. 8232, doi:10.1117/12.905091.
- 142. P.G. Schiro, M. Zhao, J.S. Kuo, T. Schneider, K.M. Koehler,
D.E. Sabath, D.T. Chiu (2012) "Sensitive and high-throughput isolation of rare
cells from peripheral blood with ensemble decision aliquot ranking" Angew.
Chem. Int. Ed. 51, 4618-4622.
- 141. F. Ye, C. Wu, Y. Jin, M. Wang, Y.H. Chan, S. Hayden, D.T. Chiu
(2012) "A new compact and highly fluorescent orange-emitting polymer dot for
specific subcellular imaging" Chem. Comm. 48, 1778-1780.
- 140. K.L. Budzinski, B.S. Fujimoto, S.M. Bajjalieh, D.T. Chiu (2011) "Measurements of the acidification kinetics of single SynaptopHluorin vesicles" Biophys. J. 101, 1580-1589.
- 139. D.R. Burnham and D.T. Chiu (2011) "Effects of aliasing on the fidelity of a two dimensional array of foci generated with a kinoform" Optics Express 19, 17121-17126.
- 138. S.A. Mutch, J. Gadd, B. Fujimoto, P. Kensel-Hammes, P. Schiro, S.M. Bajjalieh, D.T. Chiu (2011) "Determining the number of specific proteins in cellular compartments by quantitative microscopy" Nature Protocol 6, 1953-1968.
- 137. J.S. Kuo and D.T. Chiu (2011) "Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic" Lab Chip 11, 2656-2665.
- 136. F. Ye, C. Wu, Y. Jin, Y.H. Chan, X. Zhang, D.T. Chiu (2011) "Ratiometric temperature sensing with semiconducting polymer dots" J. Amer. Chem. Soc. 133, 8146-8149.
- 135. T. Schneider, D.R. Burnham, J. VanOrden, D.T. Chiu (2011) "Systematic investigation of droplet generation at T-junctions" Lab Chip 11, 2055-2059.
- 134. A.E. Sgro, A.L. Nowak, N.S. Austin, K.L. Custer, P.B. Allen, D.T. Chiu, S.M. Bajjalieh (2011) "A high-throughput method for generating uniform microislands for autaptic neuronal cultures" J. Neurosci. Meth. 198, 230-235.
- 133. M.B. Zeigler, P.B. Allen, D.T. Chiu (2011) "Probing Rotational Viscosity in Synaptic Vesicles" Biophys. J. 100, 2846-2851.
- 132. K.L. Budzinski, A.E. Sgro, B.S. Fujimoto, J.C. Gadd, N. Shuart, T. Gonen, S.M. Bajjalieh, D.T. Chiu (2011) "Synaptosomes as a platform for loading nanoparticles into synaptic vesicles" ACS Chem. Neurosci. 2, 236-241.
- 131. C. Wu, S.J. Hansen, Q. Hou, J. Yu, M. Zeigler, Y. Jin, D.R. Burnham, J.D. McNeill, J.M. Olson, D.T. Chiu (2011) "Design of highly emissive polymer blend bioconjugates for in vivo tumor targeting" Angew. Chem. Int. Ed. 50, 3430-3434.
- 130. Y.Jin, F. Ye, M.B. Zeigler, C. Wu, D.T. Chiu (2011) "Near-infrared fluorescent dye-doped semiconducting polymer dots" ACS Nano 5, 1468-1475.
- 129. Y.H. Chan, C. Wu, F. Ye, Y. Jin, P.B. Smith, and D.T. Chiu (2011) "Development of Ultrabright Semiconducting Polymer Dots for Ratiometric pH Sensing" Anal. Chem. 83, 1448-1455.
- 128. Y.H. Chan, Y. Jin, C. Wu, D.T. Chiu (2010) "Copper (II) and iron (II) ion sensing with semiconducting polymer dots" Chem. Comm 47, 2820-2822.
- 127. G.S. Yen, B. Fujimoto, T. Schneider, D.T.K. Huynh, G.D.M. Jeffries, D.T. Chiu (2010) "A rapid and economical method for profiling feature heights during microfabrication" Lab Chip 11, 974-977.
- 126. S.A. Mutch, P. Kensel-Hammes, J.C. Gadd, B.S. Fujimoto, R.W. Allen, P.G. Schiro, R.M. Lorenz, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh, D.T. Chiu (2010) "A quantitative single vesicle imaging technique reveals a subset of synaptic vesicle membrane proteins are trafficked with high precision" J. Neurosci 31, 1461-1470.
- 125. J.S. Kuo, D.T. Chiu (2011) "Controlling mass transport in microfluidic devices" Ann. Rev. Anal. Chem. 4, 275-296.
- 124. K.A.D. Gregersen, Z.B. Hill, J.C. Gadd, B.S. Fujimoto, D.J. Maly, D.T. Chiu (2010) "Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules" ACS Nano 4, 7603-7611.
- 123.G.D.M. Jeffries, R.M. Lorenz, D.T. Chiu (2010) "Ultrasensitive and High-Throughput Fluorescence Analysis of Droplet Contents with Orthogonal Line Confocal Excitation" Anal. Chem. 82, 9948-9954.
- 122. C. Wu, Y. Jin, T. Schneider, D. Burnham, and D.T. Chiu (2010) "Ultra-bright and bio-orthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry" Angew. Chem. Int. Ed. 49, 9436-9440.
- 121. C. Wu, T. Schneider, M. Zeigler, J. Yu, P.G. Schiro, D.R. Burnham, J.D. McNeill, D.T. Chiu (2010) "Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting" J. Amer. Chem. Soc. 132, 15410-15417.
- 120. D.R. Burnham, T. Schneider, D.T. Chiu (2010) "Optical-Trapping Enabled Parallel Delivery of Biological Stimuli with High Spatial and Temporal Resolution" Proc. SPIE-Int. Soc. Opt. Eng. 7762, 77621T1-77621T10.
- 119. D.E. Cohen, T. Schneider, M. Wang, D.T. Chiu (2010) "Self-digitization of sample volumes" Anal.Chem. 82, 5707-5717.
- 118. A.E. Sgro and D.T. Chiu (2010) "Droplet freezing, docking, and the exchange of immiscible phase and surfactant around frozen droplets" Lab Chip 10, 1873-1877.
- 117. G. Milne, Y. Zhao, D.T. Chiu (2010) "High precision measurement and analysis of colloidal monolayers" Anal. Chem 82, 3943-3949.
- 116. P.B.Smith, K.A. Dendramis, D.T. Chiu (2010) "Investigating lyophilization of lipid nanocapsules with fluorescence correlation spectroscopy" Langmuir 26, 10218-10222.
- 115. D.T. Chiu (2010) "Interfacing droplet microfluidics with chemical separation for cellular analysis" Anal. Bioanal. Chem. 397, 3179-3183.
- 114. M.J. Han, D.T. Chiu, E.C. Koc (2010) "Regulation of mitochondrial ribosomal protein S29 (MRPS29) expression by a 5'-upstream open reading frame" Mitochondrion 10, 274-283.
- 113. J.S. Kuo, Y. Zhao, P.G. Schiro, L. Ng, D.S.W. Lim, J.P. Shelby, D.T. Chiu (2010) "Deformability Considerations in Filtration of Biological Cells" Lab Chip 10, 837-842.
- 112. P.B. Allen, G. Milne, B.R. Doepker, D.T. Chiu (2010) "Pressure-driven laminar-flow switching for rapid exchange of solution environment around surface adhered biological particles" Lab Chip 10, 727-733.
- 111. J. Hurtig, D.T. Chiu, B. Onfelt (2010) "Intercellular nanotubes: Insights from imaging studies and beyond" Interdisciplinary Review in Nanomedicine and Nanobiotechnology 2, 260-276.
- 110. R.M. Lorenz & D.T. Chiu (2010) "Ultrasensitive analysis of individual cells via droplet microfluidics" in Chemical Cytometry; Editor Chang Lu, Wiley VCH, 143-157.
- 109. Y. Zhao, D. Shapiro, D. McGloin, D.T. Chiu, S. Marchesini (2009) "Direct observation of the transfer of orbital angular momentum to metal particles from a focused circularly polarized Gaussian beam" Optics Express 17, 23316-23322.
- 108. K.A. Dendramis & D.T. Chiu (2009) "Laser photolysis of dye-sensitized nanocapsules occurs via a photothermal pathway" J. Amer. Chem. Soc. 131, 16771-16778.
- 107. G.D.M. Jeffries, G. Milne, Y. Zhao, C. Lopez-Mariscal, D.T. Chiu (2009) "Optofluidic generation of Laguerre-Gaussian beams" Optics Express 17, 17555-17562.
- 106. K.L. Budzinski, R.W. Allen, B.S. Fujimoto, P. Kensel-Hammes, D.M. Belnap, S.M. Bajjalieh, D.T. Chiu (2009) "Large structural change in isolated synaptic vesicles upon loading with neurotransmitter" Biophys. J. 97, 2577-2584.
- 105. D.T. Chiu, R.M. Lorenz, G.D.M. Jeffries (2009) "Droplets for ultrasmall-volume analysis" Anal. Chem. 81, 5111-5118.
- 104. M.B. Zeigler & D.T. Chiu (2009) "Laser selection significantly affects cell viability following single-cell nanosurgery" Photochem. Photobiol. 85, 1218-1224.
- 103. P.B. Allen, B.R. Doepker, D.T. Chiu (2009) "High-throughput capillary-electrophoresis analysis of the contents of single mitochondria" Anal. Chem. 81, 3784-3791.
- 102. J.S. Kuo, Y. Zhao, L. Ng, G.S. Yen, R.M. Lorenz, D.S.W. Lim, D.T. Chiu (2009) "Microfabricating high-aspect-ratio structures in polyurethane-methacrylate (PUMA) disposable microfluidic devices" Lab Chip 9, 1951-1956.
- 101. J.S. Kuo, L. Ng, G.S. Yen, R.M. Lorenz, P.G. Schiro, J.S. Edgar, Y. Zhao, D.S.W. Lim, P.B. Allen, G.D.M. Jeffries, D.T. Chiu (2009) "A new
USP Class VI-compliant substrate for manufacturing disposable microfluidic devices" Lab Chip 9, 870-876.
- 100. D.T. Chiu & R.M. Lorenz (2009) "Chemistry and biology in femtoliter and picoliter volume droplets" Accounts of Chem. Res. 42, 649-658.
- 99. P.B. Allen, B.R. Doepker, D.T. Chiu (2009) "Introduction to
photolithography, soft lithography, and microfluidics" Chem. Edu. 14, 61-63.
- 98. S. Handayani, D.T. Chiu, E. Tjitra, J.S. Kuo, D. Lampah, En.
Kenangalem, L. Renia, G. Snounou, R. N. Price, N.M. Anstey, B. Russell (2009) "High deformability of Plasmodium vivax infected red blood cells under microfluidic conditions" J. of Infectious Diseases 199, 445-450.
- 97. Y. Zhao, P. Schiro, J.S. Kuo, L.Y. Ng, D.T. Chiu (2009) "A simple and rapid method for the accurate preparation of cell-spiking standards" Anal. Chem. 81, 1285-1290.
- 96. J.S. Edgar, G. Milne, Y. Zhao, C.P. Pabbati, D.S.W. Lim, D.T. Chiu (2009) "Droplet compartmentalization of chemical separations" Angew. chem. Int. Ed. 48, 2719-2722.
- 95. R.M. Lorenz, G.S. Fiorini, G.D.M. Jeffries, D.S.W. Lim, M. He, D.T. Chiu (2008) "Simultaneous generation of multiple aqueous droplets in a
microfluidic device" Anal. Chim. Acta. 630, 124-130.
- 94. P.B. Allen and D.T. Chiu (2008) "Calcium assisted glass-to-glass
bonding for fabrication of glass microfluidic devices" Anal. Chem. 80, 7153-7157.
- 93. K.A. Dendramis, P.B. Allen, P. Reid, D.T. Chiu (2008) "Spectrally
tunable uncaging of biological stimuli from nanocapsules" Chem. Comm. 4795-4797.
- 92. G. Milne, G.D.M. Jeffries, D.T. Chiu (2008) "Tunable generation
of Bessel beams with a fluidic axicon" Appl. Phys. Lett. 92, 261101.
- 91. P.B. Allen, A.E. Sgro, D.L. Chao, B.E. Doepker, J.S. Edgar, K.
Shen, D.T. Chiu (2008) "Single-synapse ablation and long-term imaging in
live C. elegans" J. Neurosci. Meth. 173, 20-26.
- 90. Y. Zhao, G. Milne, J.S. Edgar, G.D.M. Jeffries, D. McGloin, D.T.
Chiu (2008) "Quantitative force mapping in an optical vortex trap" Appl.
Phys. Lett. 92, 161111.
- 89. J.C. Gadd, C.L. Kuyper, B.S. Fujimoto, R.W. Allen, D.T. Chiu
(2008) "Sizing subcellular organelles and nanoparticles confined within
aqueous droplets" Anal. Chem. 80, 3450-3457.
- 88. P.B. Allen, D.T. Chiu (2008) "Alzheimer.s disease protein Ab1-42
does not disrupt isolated synaptic vesicles" Biochim. Biophys. Acta -
Molecular Basis of Disease 1782, 326-334.
- 87. P.B. Allen, B.R. Doepker, D.T. Chiu (2007) "Fourier transform
capillary electrophoresis with laminar flow gated pressure injection" Anal. Chem. 79, 6807-6815.
- 86. Y. Zhao, J.S. Edgar, G.D.M. Jeffries, D. McGloin, D.T. Chiu (2007) "Spin-to-Orbital Angular Momentum Conversion in a Strongly Focused Optical Beam" Phys. Rev. Lett. 99, 073901.
- 85. A.E. Sgro, P.B. Allen, D.T. Chiu (2007) "Thermoelectric manipulation of aqueous droplets in microfluidic devices" Anal. Chem. 79, 4845-4851.
- 84. G.S. Fiorini, M. Yim, G.D.M. Jeffries, P. Schiro, S.A. Mutch, R.M. Lorenz, D.T. Chiu (2007) "Fabrication Improvements for Thermoset Polyester (TPE) Microfluidic Devices" Lab Chip 7, 923-926.
- 83. Y. Zhao, B.S. Fujimoto, G.D.M. Jeffries, P.G. Schiro, D.T. Chiu (2007) "Optical gradient flow focusing" Optics Express 15, 6167-6176.
- 82. D.T. Chiu (2007) "Aqueous droplets as single-molecule reaction containers" Proc. Intl. IEEE-Transducers 07 07, 465-468.
- 81. T. Pan, G.S. Fiorini, D.T. Chiu, A.T. Woolley (2007) "In-channel atom-transfer radical polymerization of thermoset polyester microfluidic devices for bioanalytical applications" Electrophoresis 28, 2904-2911.
- 80. G.D.M. Jeffries, J.S. Kuo, D.T. Chiu (2007) "Controlled shrinkage and re-expansion of a single aqueous droplet inside an optical vortex
trap" J. Phys. Chem. B 111, 2806-2812.
- 79. D.E. Cohen, J.B. Benedict, B. Morlan, D.T. Chiu, B. Kahr (2007)
"Dyeing polymorphs: The MALDI Host 2,5-Dihydroxybenzoic Acid" Cryst.
Growth Des. 7, 492-495.
- 78. S.A. Mutch, B. Fujimoto, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh,
D.T. Chiu (2007) "De-convolving single-molecule intensity distributions
for quantitative microscopy measurements" Biophys. J. 92, 1-18.
- 77. P.G. Schiro, C.L. Kuyper, D.T. Chiu (2007) "Continuous-flow
single-molecule capillary electrophoresis with high detection efficiency"
Electrophoresis 28, 2430-2438.
- 76. G.D.M. Jeffries, J.S. Edgar, Y. Zhao, J.P. Shelby, C. Fong, D.T.
Chiu (2007) "Using polarization-shaped optical vortex traps for single
cell nanosurgery" Nano Lett. 7, 415-420.
- 75. G.D.M. Jeffries, J.S. Kuo, D.T. Chiu (2007) "Dynamic modulation
of chemical concentration in an aqueous droplet" Angew. Chem. Int. Ed.
46, 1326-1328.
- 74. R.M. Lorenz, J.S. Edgar, G.D.M. Jeffries, Y. Zhao, D. McGloin,
D.T. Chiu (2007) "Vortex-trap induced fusion of femtoliter-volume aqueous
droplets" Anal. Chem. 79, 224-228.
- 73. D.T. Chiu (2007) "Cellular manipulations in microvortices" Anal. Bioanal. Chem. 387, 17-20.
- 72. G.S. Fiorini & D.T. Chiu (2007) "Nanoscale chemical analysis of individual subcellular compartments" in New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis Editor X.N. Xu, Wiley VCH, 119-140.
- 71. C.L. Kuyper, B. Fujimoto, Y. Zhao, P. Schiro, D.T. Chiu (2006) "Accurate sizing of nanoparticles using confocal correlation spectroscopy" J. Phys. Chem. B. 110, 24433-24441.
- 70. J.S. Edgar, C.P. Pabbati, R.M. Lorenz, M. He, G.S. Fiorini, D.T. Chiu (2006) "Capillary electrophoresis separation in the presence of an immiscible boundary for droplet analysis" Anal. Chem. 78, 6948-6954.
- 69. R.M. Lorenz, J.S. Edgar, G.D.M. Jeffries, D.T. Chiu (2006) "Microfluidic and optical systems for the on-demand generation and manipulation of single femtoliter-volume aqueous droplets" Anal. Chem. 78, 6433-6439.
- 68. M. He, J.S. Kuo, D.T. Chiu (2006) "Effects of ultrasmall orifices on the electrogeneration of femtoliter-volume aqueous droplets" Langmuir 22, 6408-6413.
- 67. C.L. Kuyper, J.S. Kuo, S.A. Mutch, D.T. Chiu (2006) "Proton permeation into single vesicles occurs via a sequential two-step mechanism and is heterogeneous" J. Am. Chem. Soc. 128, 3233-3240.
- 66. C.L. Kuyper, K.L. Budzinski, R.M. Lorenz, D.T. Chiu (2006) "Real-Time Sizing of Nanoparticles in Microfluidic Channels Using Confocal Correlation Spectroscopy" J. Am. Chem. Soc. 128, 730-731.
- 65. J. Pihl, M. Karlsson, D.T. Chiu (2005) "Microfluidic technologies in drug discovery" Drug Discov. Today 10, 1377-1383.
- 64. B. Sun, S.A. Mutch, R.M. Lorenz, D.T. Chiu (2005) "Layered polyelectrolyte-silica coating for nanocapsules" Langmuir 21, 10763-10769.
- 63. M. He, J.S. Kuo, D.T. Chiu (2005) "Electro-generation of single femtoliter and picoliter-volume aqueous droplets in microfluidic systems" Appl. Phys. Lett. 87, 031916.
- 62. J.P. Shelby, J.S. Edgar, D.T. Chiu (2005) "Monitoring cell survival after extraction of a single subcellular organelle using optical trapping and pulsed-nitrogen laser ablation" Photochem. Photobiol. 81, 994-1001.
- 61. J.P. Shelby, D.S.W. Lim, J.S. Kuo, D.T. Chiu (2005) "The generation, characterization, and application of microvortices in microfluidic systems" Proc. ICMM 3, 75259.
- 60. B. Sun and D.T. Chiu (2005) "Determination of the encapsulation efficiency of individual vesicles using single-vesicle photolysis and confocal single-molecule detection" Anal. Chem. 77, 2770-2776.
- 59. M. He, J.S. Edgar, G.D.M. Jeffries, R.M. Lorenz, J.P. Shelby, D.T. Chiu (2005) "Selective encapsulation of single cells and subcellular organelles into picoliter and femtoliter-volume droplets" Anal. Chem. 77, 1539-1544.
- 58. G.S. Fiorini and D.T. Chiu (2005) "Disposable microfluidic devices: fabrication, function, and application" Biotechniques 38, 429-446.
- 57. C.L. Kuyper, G.M. Jeffries, R.M. Lorenz, D.T. Chiu (2004) "Single-molecule detection and manipulation in nanotechnology and biology" NanoFabrication for Biomedical Applications, Editor C. Kumar, Wiley-VCH, 197-225.
- 56. J.S. Kuo, C.L. Kuyper, P.B. Allen, G.S. Fiorini, D.T. Chiu (2004) "High-power light-emitting-diodes as excitation source for sensitive detection" Electrophoresis 25, 3796-3804.
- 55. B. Sun, D.S.W. Lim, J.S. Kuo, C.L. Kuyper, D.T. Chiu (2004) "Fast initiation of chemical reactions with laser-induced breakdown of a nanoscale partition" Langmuir 20, 9437-9440.
- 54. G.S. Fiorini, R.M. Lorenz, J.S. Kuo, D.T. Chiu (2004) "Rapid prototyping of thermoset polyester microfluidic devices" Anal. Chem. 76, 4697-4704.
- 53. J.P. Shelby and D.T. Chiu (2004) "Controlled rotation of biological particles in microvortices" Lab Chip 4, 168-170.
- 52. B. Sun and D.T. Chiu (2004) "Synthesis, loading, and application of individual nanocapsules for probing single-cell signaling" Langmuir 20, 4614-4620.
- 51. D.T. Chiu and O. Orwar (2004) "Functional cell-based high throughput drug screening" Drug Disc. World 5 (2), 45-51.
- 50. J.P. Shelby, S.A. Mutch, D.T. Chiu (2004) "Direct manipulation and observation of the rotational motion of single optically trapped microparticles and biological cells in microvortices" Anal. Chem. 76, 2492-2497.
- 49. R.M. Lorenz, C.L. Kuyper, P.B. Allen, L.P. Lee, D.T. Chiu (2004) "Direct laser writing on electrolessly deposited thin metal films for applications in micro and nanofluidics" Langmuir 20, 1833-1837.
- 48. M. He, C. Sun, D.T. Chiu (2004) "Concentrating solutes and nanoparticles within individual aqueous microdroplets" Anal. Chem. 76, 1222-1227.
- 47. D.S.W. Lim, J.S. Kuo, D.T. Chiu (2004) "A parametric investigation on the effect of channel topologies on electrophoretic separations" J. Chrom. A 1027, 237-244.
- 46. J.P. Shelby, J. White, K. Ganesan, P.K. Rathod, D.T. Chiu (2003) "A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes" Proc. Natl. Acad. Sci., U.S.A. 100, 14618-14622.
- 45. B. Sun and D.T. Chiu (2003) "Functional mapping of cell surface proteins with localized stimulation of single cells" Proc. SPIE-Int. Soc. Opt. Eng. 5222, 118-125.
- 44. C.L. Kuyper, G.P. Brewood, D.T. Chiu (2003) "Initiating conformation transitions of individual YOYO-intercalated DNA molecules with optical trapping" Nano Lett. 3, 1387-1389.
- 43. J. P. Shelby, D.S.W. Lim, J.S. Kuo, D.T. Chiu (2003) "Generation of ultra-high radial accelerations in microvortices" Nature 425, 38.
- 42. G.S. Fiorini, G.D.M. Jeffries, D.S.W. Lim, C.L. Kuyper, D.T. Chiu (2003) "Molding techniques for the rapid prototyping of polymeric microfluidic devices" Lab Chip 3, 158-163.
- 41. D.S.W. Lim, P. Shelby, J.S. Kuo, D.T. Chiu (2003) "Dynamic formation of ring-shaped patterns of colloidal particles in microfluidic systems" Appl. Phys. Lett 83, 1145-1147.
- 40. D.T. Chiu (2003) "Micro and nano scale chemical analysis of individual subcellular compartments" Tr. Anal. Chem. 22, 528-536.
- 39. A. Lunqvist, D.T. Chiu, O. Orwar (2003) "Electrophoretic separation and confocal laser-induced fluorescence detection at ultralow concentrations in constricted fused-silica capillaries" Electrophoresis 24, 1737-1744.
- 38. I. Rodriguez, P. Spicar-Mihalic, C. Kuyper, G. S. Fiorini, D.T. Chiu (2003) "Rapid prototyping of glass microchannels" Anal. Chim. Acta. 496, 205-215.
- 37. J.S. Kuo, P. Spicar-Mihalic, I. Rodriguez, D.T. Chiu (2003) "Electrowetting-induced droplet movement in an immiscible medium" Langmuir 19, 250-255.
- 36. B. Sun and D. T. Chiu (2003) "Spatially and temporally resolved delivery of stimuli to single cells" J. Am. Chem. Soc. 125, 3702-3703.
- 35. J. P. Shelby and D. T. Chiu (2003) "Mapping fast flows over micrometer length scales using flow-tagging velocimetry and single-molecule detection" Anal. Chem. 75, 1387-1392.
- 34. P.B. Allen, I. Rodriguez, C.L. Kuyper, R.M. Lorenz, P. Spicar-Mihalic, J. S. Kuo, D.T. Chiu (2003) "Selective electroless and electrolytic deposition of metal for applications in microfluidics: Fabrication of a microthermocouple" Anal. Chem. 75, 1578-1583.
- 33. H. Wu, T. W. Odom, D. T. Chiu, G. M. Whitesides (2003) "Fabrication of complex three-dimensional microchannels systems in PDMS" J. Am. Chem. Soc. 125, 554-559.
- 32. J. Sinclair, J. Pihl, J. Olofsson, M. Karlsson, K. Jardemark, D.T. Chiu, O. Orwar (2002) "A cell-based bar-code reader for high-throughput screening of ion channel ligand interactions" Anal. Chem. 74, 6133-6138.
- 31. M. Karlsson , K. Sott, M. Davidson, A.S. Cans, P. Linderholm, D.T. Chiu, O. Orwar (2002) "Formation of lipid nanotube-vesicle networks of complex topologies using microelectrofusion" Proc. Natl. Acad. Sci., U.S.A. 99, 11573-11578.
- 30. C.L. Kuyper & D.T. Chiu (2002) "Optical Trapping: A versatile technique for biomanipulation" Appl. Spec. 56, 300A-312A.
- 29. J. Seo, C.L. Kuyper, D.T. Chiu, L.P. Lee (2002) "Cyclic SixNy microfluidic devices for single-molecule manipulation and detection capability" Proc. Ann. Intl. IEEE-EMBS. 2, 363-368.
- 28. D.T. Chiu (2001) "A microfluidics platform for cell fusion" Curr. Opin. Chem. Biol. 5, 609-612.
- 27. N.L. Jeon, D.T. Chiu, C.J. Wargo, H. Wu, I.S. Choi, J.R. Anderson, G.M. Whitesides (2002) "Design and fabrication of integrated passive valves and pumps for flexible polymer 3D microfluidic systems" Biomedical Microdevices 4, 117-121.
- 26. R. Ismagilov, D. Rosmarin, P.J.A. Kenis, D.T. Chiu, G.M. Whitesides (2001) "Pressure-driven laminar flow in tangential microchannels: An elastomeric microfluidic switch" Anal. Chem. 73, 4682-4687.
- 25. M.L. Chabinyc, D.T. Chiu, J.C. McDonald, A.D. Stroock, J.F. Christian, A.M. Karger, G.M. Whitesides (2001) "An integrated fluorescence detectiodetection system in poly(dimethylsiloxane) for microfluidic applications" Anal. Chem. 73, 4491-4498.
- 24. D.T. Chiu, E. Pezzoli, H. Wu, A.D. Stroock, G.M. Whitesides (2001) "Using three-dimensional microfluidic networks for solving computationally hard problems" Proc. Natl. Acad. Sci., U.S.A. 98, 2961-2966.
- 23. S.K.W. Dertinger, D.T. Chiu, N.L. Jeon, G.M. Whitesides (2001) "Generation of gradients having complex shapes using microfluidic networks" Anal. Chem. 73, 1240-1246.
- 22. Karlsson, A. Strömberg, F. Ryttsén, D.T. Chiu, O. Orwar (2001) "Microfluidic device for combinatorial fusion of liposomes and cells" Anal. Chem. 73, 126-130.
- 21. C.F. Wilson, G. Simpson, D.T. Chiu, O. Orwar, N. Rodriguez, R.N. Zare (2001) "Nanoengineered structures for holding and manipulating liposomes and cells" Anal. Chem. 73, 787-797.
- 20. D.T. Chiu, M. Davidson, A. Strömberg, F. Ryttsén, O. Orwar (2001) "Electrical and optical methods for the manipulation and analyses of single cells" Proc. SPIE-Int. Soc. Opt. Eng. 4255, 1-8.
- 19. C.F. Wilson, D.T. Chiu, R.N. Zare, A. Strömberg, A. Karlsson, O. Orwar (2001) "Confining and probing single molecules in synthetic liposomes" Single Molecule Spectroscopy: Nobel Conference Lectures, Editors R. Rigler, M. Orrit, and T. Basche, Springer-Verlag, Berlin Heidelberg.
2000 and Prior
- 18. N.L. Jeon, S.K.W. Dertinger, D.T. Chiu, I.S. Choi, A.D. Stroock, G.M. Whitesides (2000) "Generation of solution and surface gradients using microfluidic systems" Langmuir 16, 8311-8316.
- 17. F. Ryttsén, C. Farre, C. Brennan, S.G. Weber, K. Jardemark, D.T. Chiu, O. Orwar (2000) "Characterization of single-cell electroporation by using patch clamp and fluorescence microscopy" Biophys. J. 79, 1993-2001.
- 16. A. Stroock, M. Weck, D.T. Chiu, W. Huck, P.J.A. Kenis, R. Ismagilov, G.M. Whitesides (2000) "Patterning electro-osmotic flow with patterned surface charge" Phys. Rev. Lett. 84, 3314-3317.
- 15. J.R. Anderson, D.T. Chiu, J.C. McDonald, R.J. Jackman, O. Cherniavskaya, H. Wu, S. Whitesides, G.M. Whitesides (2000) "Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping" Anal. Chem. 72, 3158-3164.
- 14. D.T. Chiu, N.L. Jeon, S. Huang, R.S. Kane, C.J. Wargo, I.S. Choi, D.E. Ingber, G.M. Whitesides (2000) "Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems" Proc. Natl. Acad. Sci., U.S.A. 97, 2408-2413.
- 13. J.C. McDonald, D.C. Duffy, J.R. Anderson, D.T. Chiu, H. Wu, G.M. Whitesides (2000) "Fabrication of microfluidic systems in poly(dimethyl siloxane)" Electrophoresis 21, 27-40.
- 12. A. Strömberg, F. Ryttsén, D.T. Chiu, M. Davidson, P. Eriksson, C. Wilson, O. Orwar, R.N. Zare (2000) "Manipulating the genetic identity and biochemical surface properties of individual cells with electric-field-induced fusion" Proc. Natl. Acad. Sci., U.S.A. 97, 7-11.
- 11. D.T. Chiu, C.F. Wilson, A. Karlsson, A. Danielsson, A. Lundqvist, A. Strömberg, F. Ryttsén, M. Davidson, S. Nordholm, O. Orwar, R.N. Zare (1999) "Manipulating the biochemical nanoenvironment around single molecules contained within vesicles" Chemical Physics 247, 133-139.
- 10. D.T. Chiu, C.F. Wilson, F. Ryttsén, A. Strömberg, C. Farre, A. Karlsson, S. Nordholm, A. Gaggar, B.P. Modi, A. Moscho, R.A. Garza-Lop z, O. Orwar, R. N. Zare (1999) "Chemical transformations in individual ultrasmall biomimetic containers" Science 283, 1892-1895.
- 9. D.T. Chiu and R.N. Zare (1998) "Assaying for peptides in individual Aplysia neurons with mass spectrometry" Proc. Natl. Acad. Sci., U.S.A. 95, 3338-3340.
- 8. S.J. Lillard, D.T. Chiu, R.H. Scheller, R.N. Zare, S.E. Rodriguez-Cruz, E.R. Williams, O. Orwar, M. Sandberg, J.A. Lunqvist (1998) "Separation and characterization of amines from individual atrial gland vesicles of Aplysia californica" Anal. Chem. 70, 3517-3524.
- 7. D.T. Chiu, S.J. Lillard, R.H. Scheller, R.N. Zare, S.E. Rodriguez-Cruz, E.R. Williams, O. Orwar, M. Sandberg, J.A. Lunqvist (1998) "Probing single secretory vesicles with capillary electrophoresis" Science 279, 1190-1193.
- 6. D.T. Chiu, A. Hsiao, A. Gaggar, R.A. Garza-Lopéz, O. Orwar, R.N. Zare (1997) "Injection of ultrasmall samples and single molecules into tapered capillaries" Anal. Chem. 69, 1801-1807.
- 5. D.T. Chiu and R.N. Zare (1997) "Optical detection and manipulation of single molecules in room-temperature solutions" Chemistry - A European Journal 3, 335-339.
- 4. A. Moscho, O. Orwar, D.T. Chiu, B. Modi, R.N. Zare (1996) "Rapid preparation of giant unilamellar vesicles" Proc. Natl. Acad. Sci., U.S.A. 93, 11443-11447.
- 3. D.T. Chiu and R.N. Zare (1996) "Biased diffusion, optical trapping, and manipulation of single molecules in solution" J. Am. Chem. Soc. 118, 6512-6513.
- 2. S. Nie, D.T. Chiu, R.N. Zare (1995) "Real-time detection of single molecules in solution by confocal fluorescence microscopy" Anal. Chem. 67, 2849-2857.
- 1. S. Nie, D.T. Chiu, R.N. Zare (1994) "Probing individual molecules with confocal fluorescence microscopy" Science 266, 1018-1021.