June 29, 2022
New publication in the Lancet Microbe on CRISPR detection of TB in adults and children with HIV
Categories: HIV and Co-Infections, Publication
Mycobacterium tuberculosis (TB) remains a major factor in global morbidity and mortality, especially for adults and children with HIV. Coinfection of HIV and tuberculosis is uniquely dangerous, as the depression of normal immune response to infection in persons with HIV can lead to both severe illness and the underdiagnosis of TB when using sputum-based assays. Collecting sputum from young children presents further issues.
A new molecular diagnostics study by UW Global WACh in collaboration with Tulane University and other partners including Baylor College of Medicine, Baylor Children’s Foundation-Eswatini, University of Nairobi and Kenyatta National Hospital in Kenya, to study the effectiveness of CRISPR-based assay detection of M. tuberculosis cell-free DNA (Mtb-cfDNA) in seropositive adults and children was published in The Lancet Microbe May 2022 edition. (more…)