The HaRP study (PI: Collins): HaRP stands for Harm Reduction with Pharmacotherapy. This is the follow-up to Project Vivitrol. In this four-arm, NIH-funded randomized controlled trial, we are testing extended-release naltrexone and harm reduction counseling as ways to reduce alcohol-related harm and improve quality of life among homeless individuals with alcohol dependence. (Click Here to view the study protocol)

The HaRT-S study (PI: Collins): HaRT-S stands for Harm Reduction Treatment for Smoking. The purpose of the HaRT-S is to develop an innovative and empirically informed and client-driven alternative to traditional smoking cessation interventions. The HaRT-S will feature a small, single-arm pilot trial (N=27) of the developed program with individuals with the lived experience of homelessness and smoking dependence.

The King County Mental Health Court and Veterans Court Evaluation (Co-PIs: Clifasefi and Collins): We have been contracted by King County to qualitatively evaluate the Mental Health and Veterans Courts of King County to document their mechanisms of action and how they compare to other, similar models in the US.

The LEAP project (PI: Clifasefi): LEAP is an NIH-funded project that entails the community-based development and evaluation of harm-reduction programming for formerly chronically homeless people with alcohol dependence who are living in a Housing First apartment (i.e., immediate, permanent, low-barrier, supportive housing where sobriety is not required) building in Seattle.

The Navigation Center Evaluation (Co-PIs: Clifasefi and Collins): We have been contracted by the City of Seattle to qualitatively and quantitatively evaluate the new Navigation Center, a short-term shelter that aims to help homeless individuals navigate into permanent housing.


Project Vivitrol® (PI: Collins): A pilot study of extended-release naltrexone as medication support for harm reduction counseling among currently and formerly chronically homeless individuals with alcohol dependence. Participants in this study were able to define their own goals—abstinence and use reduction were not required. (Click here and here to view results).

The HaRT-A study (PI: Collins): HaRT-A stands for Harm Reduction Treatment for Alcohol use disorders. The purpose of this study was to develop and conduct a pilot randomized controlled trial evaluating the initial effectiveness of an individual harm-reduction treatment for homeless individuals with AUDs. This study comprised of a 4-session individual, behavioral AUD intervention. Components included providing personalized alcohol feedback, eliciting participants’ harm reduction goals, building motivation, and supporting the use of safer drinking strategies using a nonjudgmental, empathetic stance, and acceptance of participants wherever they were along the spectrum of behavior change.

The LEAD evaluation (PI: Collins & Clifasefi): The Law Enforcement Assisted Diversion (LEAD) is a pre-booking diversion pilot program currently in place in the Belltown neighborhood of Seattle and the Skyway area of unincorporated King County, WA. LEAD was developed to allow law enforcement officers to divert low-level drug and prostitution offenders to community-based treatment and support services instead of jail and prosecution. This program was developed by the King County Prosecuting Attorney’s Office, the Seattle City Attorney’s Office, the Seattle Police Department, the King County Sheriff’s Office, the King County Executive, the Mayor’s Office, The Washington State Department of Corrections, The Defender Association, the ACLU of Washington, REACH homeless outreach and community members. (Click here for more information, click here for a video that features LEAD, and here for results)

Project M2M: Project Match to Motivation (M2M) was a three-year, NIH-funded randomized controlled trial. In this study, we tested the efficacy of two web-based motivational enhancement interventions in reducing alcohol-related harm among college drinkers. We also tested whether we can match certain interventions to participants’ level of motivation to support less harmful drinking. Click here for the primary paper or click here for a secondary qualitative paper