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Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance

November 25, 2015 in Publications, Brain

Ellen Schur and Kenneth Maravilla's research group in the UW Medicine Departments of General Internal Medicine and Epidemiology recently used Digital Pathology services at the Pathology Digital Imaging Core Facility to quantify glial fibrillary acidic protein (GFAP) staining in autopsy brain specimens.  Their findings in the journal Obesity in November 2015 link hypothalamic gliosis to insulin resistance in humans and suggest that the link is independent of the level of adiposity.

The publication is cited below. Follow the PubMed link to access the full article.

Related Publications

  1. Schur EA, Melhorn SJ, Oh SK, Lacy JM, Berkseth KE, Guyenet SJ, Sonnen JA, Tyagi V, Rosalynn M, De Leon B, Webb MF, Gonsalves ZT, Fligner CL, Schwartz MW, Maravilla KR. Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity (Silver Spring). 2015 Nov;23(11):2142-8. doi: 10.1002/oby.21248. PMCID:PMC4634110 PMID:26530930

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