September 17, 2020

Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville, Tennessee

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): health care workers, immunity, testing

• Anti-SARS-CoV-2 antibody levels declined over 60 days among all 19 health care personnel in Tennessee who had anti–SARS-CoV-2 antibodies at baseline. In 11 (58%), antibody levels declined substantially enough that they tested negative at 60 days, while 8 (42%) remained seropositive after 60 days. The authors conclude that cross-sectional seroprevalence studies may underestimate rates of prior infections because antibodies may only be transiently detectable following infection.

Patel et al. (Sept 17, 2020). Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville, Tennessee. JAMA. https://doi.org/10.1001/jama.2020.18796