Alliance for Pandemic Preparedness

October 26, 2020

Outcomes of COVID-19 Related Hospitalization among People with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): A Prospective Observational Study

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HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19 in a study across more than 200 centers in the UK. Individuals presenting to the clinics who were HIV-positive were younger (median 56 versus 74 years) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. Nearly 92% of HIV-positive participants were taking antiretroviral therapy. While the overall cumulative day-28 mortality was similar for HIV-positive and HIV-negative groups (27% vs. 32%), among individuals younger than 60, HIV-positive status was associated with greater mortality (21% vs. 10%), and mortality was higher among people with HIV after adjusting for age (aHR = 1.47). 

Geretti et al. (Oct 23, 2020). Outcomes of COVID-19 Related Hospitalization among People with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): A Prospective Observational Study. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1605