Alliance for Pandemic Preparedness

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Tag: risk factors

June 7, 2021

The Role of HIV Infection in the Clinical Spectrum of COVID-19 a Population-Based Cohort Analysis Based on US National COVID Cohort Collaborative (N3C) Enclave Data

[Pre-print, not peer-reviewed] A study using electronic health record data from 54 clinical sites in the National COVID Cohort Collaborative found that people living with HIV (PLWH, n=13,170) had a higher risk of COVID-19 death and hospitalization after adjusting for age and sex. The associations were attenuated, but remained significant, after adjusting for smoking status,…

May 14, 2021

Comparison and Impact of COVID-19 for Patients with Cancer: A Survival Analysis of Fatality Rate Controlling for Age, Sex and Cancer Type

A survival analysis of UK cancer patients (N=4,606) found that those with a SARS-CoV-2 diagnosis between March-October 2020 had a higher risk of death compared to patients without SARS-CoV-2. The risk of death within 21 days post SARS-CoV-2 detection was over 10-fold higher than among those without SARS-CoV-2 infection in patients with melanoma, hematological malignancies,…

May 11, 2021

Severe COVID-19 in People with Type 1 and Type 2 Diabetes in Sweden: A Nationwide Retrospective Cohort Study

Type 2 diabetes was associated with increased risk of COVID-19-related hospitalization (HR=2.22), admission to ICU (HR=2.49), and death (HR=2.19) in a nationwide study in Sweden that compared adult patients with type 2 diabetes (n=44,639) to age- and sex-matched controls. Risks for COVID-19 related outcomes remained independently associated with type 2 diabetes after further adjustment for…

May 7, 2021

Risk Factors For Infection And Health Impacts Of The Covid-19  Pandemic In People With Autoimmune Diseases

A prospective cohort study of persons with autoimmune or inflammatory conditions (N=4,666)  found that persons with diabetes (OR=1.7), cardiovascular disease (OR=1.7) and kidney disease  (OR=1.8) and patients taking glucocorticoid drugs (OR=1.4) had higher risks of COVID-19. Interruptions to healthcare were common, and persons with changes in their ability to pay for  healthcare costs and those…

Risk of COVID-19 in Rheumatoid Arthritis: A National Veterans  Affairs Matched Cohort Study in At-Risk Individuals

A matched cohort study of US veterans (N=66,772) found that persons with rheumatoid arthritis had  a higher risk of COVID-19 disease (HR=1.25) and COVID-19 associated hospitalization or death  (HR=1.35) compared to age-, sex-, and Veterans Administration-site-matched persons without  rheumatoid arthritis. Persons on immunosuppressant drugs (DMARDS and prednisone) had the highest risk of COVID-19 and severe…

April 1, 2021

Risk Factors Associated With SARS-CoV-2 Infections, Hospitalization, and Mortality Among US Nursing Home Residents

Individual-level factors were more likely to be associated with risk of SARS-CoV-2-related hospitalization and death than risk of SARS-CoV-2 infection. In a retrospective longitudinal cohort study of over 482,000 long-stay nursing home residents, risk of hospitalization was associated with BMI >45; male sex; Hispanic, Black, or Asian race/ethnicity; comorbidities; and older age (>90 years). In…

Association Between Risk Factors for Complications From COVID-19, Perceived Chances of Infection and Complications, and Protective Behavior in the US

US adults with more medical risk factors associated with COVID-19 adverse outcomes perceived they had a higher chance of hospitalization or death if they were infected compared to those without risk factors in a nationally representative cross-sectional study conducted from November to December 2020 (n=5,910). Respondents with 3 or more medical risk factors perceived a…

March 8, 2021

Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020

Among 148,494 U.S. adults diagnosed with COVID-19 between March-December 2020, individuals with a BMI near the threshold between healthy weight and overweight generally had the lowest risks for hospitalization, ICU admission, and death, with higher risks associated with higher BMI. Obesity was a risk factor for hospitalization and death, particularly among adults aged <65 years….

March 4, 2021

Non-Steroidal Anti-Inflammatory Agent Use May Not Be Associated with Mortality of Coronavirus Disease 19

In a study of patients with COVID-19 using non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen, there was no significant difference in all-cause mortality between the groups (4% vs 3%, HR=1.33, 95% CI: 0.63-2.88) after using propensity score matching to create comparable groups of treated and untreated patients (n=397 data pairs). There were also no significant differences…

March 1, 2021

Exploratory Analysis of Immunization Records Highlights Decreased SARS-CoV-2 Rates in Individuals with Recent Non-COVID-19 Vaccinations

An exploratory analysis of immunization records from the Mayo clinic found that receipt of multiple vaccines within the past five years were associated with protection from SARS-CoV-2 infection.  In an analysis of medical records from 137,037 individuals tested for SARS-CoV-2 by PCR , receipt of vaccines for polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella,…

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