Alliance for Pandemic Preparedness

November 17, 2020

SARS-CoV-2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth

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In a multicenter study of children hospitalized with COVID-19 in New York, New Jersey, and Connecticut (n=281), over half had respiratory disease and 69/281 (25%) had multi-system inflammatory syndrome in children (MIS-C). Obesity and low blood oxygen levels (hypoxia) on admission predicted severe respiratory disease, while lower absolute lymphocyte count predicted severe MIS-C. Neither race/ethnicity nor socioeconomic status were associated with disease severity. 267 (95%) children were discharged to home and 7 (2%) died.

Fernandes et al. (Nov 16, 2020). SARS-CoV-2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2020.11.016