Alliance for Pandemic Preparedness

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Tag: children

June 14, 2021

Comparison of Symptoms and RNA Levels in Children and Adults With SARS-CoV-2 Infection in the Community Setting

SARS-CoV-2 RNA levels, as determined by cycle threshold (Ct) values, were significantly higher in symptomatic compared to asymptomatic individuals, and no significant differences in RNA levels were detected between adults and children, according to results from a community-based cross-sectional study in King County, Washington. Among 555 SARS-CoV-2–positive participants, 47 of 123 children (38%) were asymptomatic…

International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries

A cohort study of children and adolescents (n=671) from France, Germany, Spain, Singapore, the UK, and the US found varying trends in COVID-19 hospitalizations and complications between countries, with hospitalizations in the cohort mirroring those of national-level pediatric hospitalization trends for most countries with available data. Laboratory values for 16 assays were analyzed, which indicated…

Risk Factors for Hospitalization Disease Severity and Mortality in Children and Adolescents with COVID-19 Results from a Nationwide German Registry

[Pre-print, not peer-reviewed] A cohort study of children and adolescents (n=1,501) who were admitted to the hospital between March 18, 2020 and April 30, 2021 in Germany and who tested positive for SARS-CoV-2 found that although approximately half of the cohort was not admitted to the hospital due to COVID-19, 72% had infection-related symptoms during…

June 11, 2021

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2

A retrospective cohort study of persons with SARS-CoV-2 infection diagnosed between April and June 2020 in 7 US states identified 248 cases of multisystem inflammatory syndrome in children (MIS-C) in persons <21 years of age. The corresponding incidence of MIS-C was 5.1 per 100,000 person-months and 316 persons per 1,000,000 (0.0003%) SARS-CoV-2 infections. Incidence was…

First-Dose ChAdOx1 and BNT162b2 COVID-19 Vaccines and Thrombocytopenic, Thromboembolic and Hemorrhagic Events in Scotland

Compared to those who received one dose of the Pfizer-BioNTech COVID-19 vaccine, receipt of one dose of the Oxford-AstraZeneca vaccine was associated with a higher risk of idiopathic thrombocytopenic purpura (ITP), a blood disorder involving low platelet counts, during 0–27 days after vaccination (adjusted RR = 5.8), with an estimated incidence of 1.13 cases per 100,000…

June 8, 2021

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

29% of pediatric US COVID-19 patients aged ≤18 years (n=43,465) had at least one underlying medical condition, according to an analysis of data collected from more than 800 US hospitals from March 2020 to January 2021.  The most common diagnosed conditions were asthma (10%), neurodevelopmental disorders (4%), anxiety and fear-related disorders (3%), depressive disorders (3%),…

June 3, 2021

Transient Cardiac Injury in Adolescents Receiving the BNT162b2 mRNA COVID-19 Vaccine

Mild perimyocariditis following vaccination with the Pfizer-BioNTech vaccine was reported in 7 adolescent males aged 16-18 years across 3 pediatric medical centers in Israel. Patients presented with chest pain 1-3 days following vaccination, with symptoms beginning following the second dose in 6 of the 7 patients. All cases were mild, and none required cardiovascular or…

May 28, 2021

6-Month Multidisciplinary Follow-up and Outcomes of Patients with Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) at a UK Tertiary Paediatric Hospital: A Retrospective Cohort Study

Organ-specific sequelae were uncommon at the 6-month follow-up in a cohort of children aged <18 years (median age 10.2 years) diagnosed with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (n=46). Echocardiograms were normal in 96% of patients, and gastrointestinal symptoms were only present in 13% of patients at 6 months among those with baseline…

May 27, 2021

Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding

In a cohort study of individuals aged <18 years who were hospitalized with COVID-19 (n=32), those diagnosed with multisystem inflammatory syndrome in children (MIS-C) (n=16) had significantly higher levels of cytokine and chemokines, such as IL-6 and IL-8, and were more likely to have anti-SARS-CoV-2 antibody positivity (75% vs 44%) compared to those without MIS-C….

May 21, 2021

Persistence of SARS-CoV-2-Specific IgG in Children 6 Months After Infection, Australia

A longitudinal cohort study of Australian adults (N=32) and children (N=22) with SARS-CoV-2 infection who were asymptomatic or had mild symptoms detected similar levels of specific IgG antibodies 6 months after infection in both children and adults. There was no significant difference in geometric mean antibody concentration from 43 to 195 days after infection, suggesting…

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