Alliance for Pandemic Preparedness

November 18, 2020

Secondary Attack Rate and Family Clustering of SARS-CoV-2 Infection in Children of Healthcare Workers with Confirmed COVID-19

Category:

Topic:

Keywords (Tags):

Seropositivity against SARS-CoV-2 was found in 45% of children in households with a parent who is a healthcare worker and who had confirmed COVID-19. Secondary cases appeared to cluster in certain households, with 95% seropositivity among children in households with at least one secondary transmission. In a cohort study of 44 children from 21 households with a parent who is a healthcare worker with COVID-19 from five cities in in the UK, 45% (20 of 44) of children were seropositive for SARS-CoV-2 IgG. There was evidence of clustering of the secondary transmissions in certain households, with a 95% secondary attack proportion (20 of 21) among the children in the 9 households with at least 1 secondary case compare to no evidence of transmission among the 23 children in the 12 households without a secondary case. 

Ladhani et al. (Nov 17, 2020). Secondary Attack Rate and Family Clustering of SARS-CoV-2 Infection in Children of Healthcare Workers with Confirmed COVID-19. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1737