December 16, 2020

Neuroimaging Manifestations in Children with SARS-CoV-2 Infection: A Multinational, Multicentre Collaborative Study

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): children, clinical characteristics

A study of neuroimaging manifestations in 38 children from 8 countries identified acute- and delayed-phase SARS-CoV-2-related central nervous system abnormalities ranging from mild to severe. The most common imaging patterns observed were immune-mediated disseminated encephalomyelitis-like changes of the brain (n=16), myelitis (n=8), and neural enhancement (n=13). Splenial lesions (n=7) and myositis (n=4) were predominantly observed in children with multisystem inflammatory syndrome. While most children had favorable outcomes, fatal atypical CNS co-infections were observed in four previously health children.

Lindan et al. (Dec 16, 2020). Neuroimaging Manifestations in Children with SARS-CoV-2 Infection: A Multinational, Multicentre Collaborative Study. The Lancet Child & Adolescent Health. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30362-X/fulltext