Alliance for Pandemic Preparedness

December 30, 2020

Immune Deficiency Is a Risk Factor for Severe COVID‐19 in People Living with HIV

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Among 175 people living with HIV in the UK, US, and Spain, a current CD4 T-cell count of <350 cells/µL was independently associated with a 2.85-fold risk for developing severe COVID-19. A lower nadir CD4 T-cell count of <200 cells/µL was associated with mortality. No significant differences in risk of severe or critical COVID-19 were detected by gender, ethnicity, obesity, detectable HIV RNA, prior AIDS‐defining illness, tenofovir, or protease inhibitor use in the current antiretroviral treatment.

Hoffmann et al. (Dec 27, 2020). Immune Deficiency Is a Risk Factor for Severe COVID‐19 in People Living with HIV. HIV Medicine. https://doi.org/10.1111/hiv.13037