Alliance for Pandemic Preparedness

January 14, 2021

Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States

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[pre-print, not peer reviewed] Genomic virus surveillance has identified one of the most prevalent SARS-CoV-2 variants in the US, referred to as 20C-US. Earliest 20C-US genomes have been traced in the southern US as early as late May. 20C-US has acquired up to 7 non-synonymous mutations with implications for efficient and accurate virus production, including a Q677H mutation in the spike protein. The authors predict that 20C-US may be the most dominant variant in the US.

Pater et al. (Jan 13, 2021). Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States. Pre-print downloaded Jan 14 from https://www.biorxiv.org/content/10.1101/2021.01.11.426287v1