Alliance for Pandemic Preparedness

January 26, 2021

Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry

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Greater pack-years of smoking was associated with worse COVID-19 outcomes in a cohort of 7,102 SARS-CoV-2 positive patients with full smoking information. Patients who smoked between 10-30 pack years had 1.4-times the odds of hospitalization compared to never smokers, while patients who smoked more than 30 pack-years had 2.3 -times the odds of hospitalization and almost a 2-fold increase in odds of death. Adjusting for comorbidities weakened the association of smoking with adverse outcomes, as the association between cumulative smoking and adverse COVID-19 outcomes is likely mediated in part by comorbidities. Similar odds ratios were seen in both current and former smokers.

Lowe et al. (Jan 25, 2021). Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2020.8360