February 1, 2021

Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, pregnancy

IgG antibodies to SARS-CoV-2 from pregnant women with symptomatic or asymptomatic SARS-CoV-2 infection were transferred across the placenta, and cord antibody concentrations were positively correlated with maternal IgG concentrations (r=0.9). IgG antibodies were detected in cord blood from 72 of 83 newborns (87%), while IgM antibodies were not detected in any cord blood samples. Eleven infants were seronegative: 5 (45%) were born to mothers with IgM antibody only, and 6 (55%) were born to mothers with significantly lower IgG concentrations compared to mothers of seropositive infants.

Flannery et al. (Jan 29, 2021). Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2021.0038