Alliance for Pandemic Preparedness

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Tag: pregnancy

June 15, 2021

COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy — Eight Integrated Health Care Organizations, United States, December 14, 2020–May 8, 2021

As of May 8, 2021, 16% (22,197 of 135,968) of pregnant women identified in CDC’s Vaccine Safety Datalink, which includes integrated health systems from 7 US states, have received ≥1 dose of a COVID-19 vaccine during pregnancy. Of those initiating vaccination 68% have completed either a 1- or 2-dose series. Vaccination during pregnancy was highest…

June 3, 2021

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

[Pre-print, not peer-reviewed] SARS-CoV-2 RNA was detected in 23 placentas (41%) from a cohort of 55 women who had SARS-CoV-2 infection during late pregnancy and had positive PCR results at delivery. Among infected placentas, three had high viral content and were obtained from mothers who presented with severe COVID-19 and had perinatal adverse outcomes. Examination…

June 2, 2021

Stopping the Misinformation BNT16b2 COVID-19 Vaccine Has No Negative Effect on Women’s Fertility

[Pre-print, not peer-reviewed] A study of 47 women undergoing in vitro fertilization (IVF) in Israel found no significant differences in IVF cycle outcomes in all participants prior to and after receiving the Pfizer-BioNTech vaccine, suggesting that vaccination has no negative effect on fertility using assisted reproductive technology. No significant differences were observed in the number…

May 24, 2021

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 Infection at the Time of Birth in England: National Cohort Study

A population-based cohort study of pregnant persons in England (n = 342,080) in the context of universal screening for SARS-CoV-2 at delivery hospitalization found that SARS-CoV-2 infection was more common among those who were younger, of non-white ethnicity, pregnant for the first time, resided in the most deprived areas, or had comorbid conditions. Risk of…

May 21, 2021

Efficient Maternal to Neonatal Transfer of Antibodies against SARS-CoV-2 and BNT162b2 MRNA COVID-19 Vaccine

A multicenter study of pregnant persons in Israel (N=213) found that the Pfizer-BioNTech vaccine elicited strong maternal IgG response and produced similar IgG titers in the fetus 15 days after the first dose. Among study participants who were infected with SARS-CoV-2 during pregnancy, those infected in the third trimester had lower rates of antibody transfer…

May 19, 2021

Pregnancy and Birth Outcomes after SARS-CoV-2 Vaccination in Pregnancy

[Pre-print, not peer-reviewed] The prevalence of adverse maternal or neonatal outcomes was the same among pregnant women who received a COVID-19 vaccine during pregnancy and unvaccinated pregnant women (5%). Findings are based on an analysis of a delivery cohort (n=2,002) created by matching a delivery database from the Mayo Clinic with a comprehensive vaccine registry….

May 13, 2021

Perinatal Outcomes During the COVID-19 Pandemic in Ontario, Canada

There were no differences observed in the frequency of preterm birth (7.5%) and stillbirth (0.5%) between a cohort of births during the COVID-19 pandemic (n=67,747) occurring between March and September 2020 and a cohort of pre-pandemic births (n=348,633) occurring within the same calendar period between 2015 and 2019 according to administrative data in Ontario, Canada. …

Adverse Pregnancy Outcomes, Maternal Complications, and Severe Illness among U.S. Delivery Hospitalizations with and without a COVID-19 Diagnosis

Adverse pregnancy outcomes occurred more frequently among US women with documented COVID-19 diagnosis at delivery hospitalization compared to those without diagnosis (4.4% vs 0.8%) in a large study including 703 hospitals (n=489,471 delivery hospitalizations; 1.3% of patients with COVID-19) between March and September 2020. In analyses adjusted for confounders, COVID-19 diagnosis was associated with a…

May 12, 2021

Passive and Active Immunity in Infants Born to Mothers with SARS-CoV-2 Infection during Pregnancy: Prospective Cohort Study

[Pre-print, not peer-reviewed] In a cohort of US mothers testing positive for SARS-CoV-2 during pregnancy (n=145), anti-SARS-CoV-2 antibodies were detected in 65% and 58% of maternal and cord blood samples at delivery, respectively. The IgG transplacental transfer ratio was significantly higher among women receiving their first maternal positive PCR test 60-180 days before delivery compared…

May 4, 2021

Severe Acute Respiratory Syndrome Coronavirus 2: A Canary in the Coal Mine for Public Safety Net Hospitals

Among 350 women admitted for delivery at a safety net hospital in Maricopa County, Arizona in July 2020, women with refugee status (n=45) had a 2-fold higher prevalence of PCR-positive SARS-CoV-2 infection compared to nonrefugee patients (18% vs 9%). Johnson-Agbakwu et al. (Mar 21, 2021). Severe Acute Respiratory Syndrome Coronavirus 2: A Canary in the Coal…

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