Alliance for Pandemic Preparedness

February 8, 2021

COVID-19 Literature Situation Report Feb 8, 2021

Category:

The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.

Today’s summary is based on a review of 910 articles (828 published, 82 in preprint)

Key Takeaways

  • Sequencing of SARS-CoV-2 genomes collected from testing facilities in the U.S. between December 2020 to January 2021 found multiple independent introductions of the B.1.1.7 variant into the U.S. by late November 2020, with community transmission leadings to its spread to 30 or more states as of January 2021. More
  • A systematic review and meta-analysis of remdesivir for the treatment of COVID-19 showed significant improvement in the 28-day recovery rate, need for low flow oxygen support through day 14, and mechanical ventilation or extracorporeal membrane oxygenation requirement through 14-28 days of follow-up among those receiving remdesivir. More
  • A study using a live virus neutralization assay to compare potency of neutralization between people who had been infected with SARS-CoV-2 or had received the Moderna COVID-19 vaccine against a panel of SARS-CoV-2 variants showed that antibodies in sera from both groups were effective at neutralizing the B.1.1.7 variant. More
  • Among healthcare workers who received a single dose of the Pfizer/BioNTech vaccine, those who had SARS-CoV-2 infection 30-60 days prior to vaccination (n = 36) had significantly higher antibody levels at 3 weeks post-vaccination than individuals with no prior infection (n = 152). More

Article Summaries

Other Resources and Commentaries

Attachments

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LitRep_20210208
COVID-19 Literature Situation Report Feb 8, 2021