Alliance for Pandemic Preparedness

February 9, 2021

Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study

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The overall rate of pregnancy complications was similar between SARS-CoV-2 infected and non-infected women in a population-based study in Spain (n=2,225). Pregnancy complications (miscarriage, preeclampsia, preterm delivery, perinatal death, small-for-gestational age, or neonatal admission) occurred in 43 (14%) of 317 SARS-CoV-2-infected women compared to 268 (14%) of 1,908 non-infected women. However, higher rates of preterm delivery (17% vs 7%) and intrapartum fetal distress (19% vs 9%) were observed among women with symptomatic infection compared to those with asymptomatic infection, while those with asymptomatic infection had similar rates to non-infected women. Among 143 SARS-CoV-2 positive pregnancies analyzed, 43% newborns were positive for IgG antibodies and no vertical transmission of SARS-CoV-2 was observed.

Crovetto et al. (Feb 8, 2021). Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab104