February 10, 2021

Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): pregnancy

An observational cohort study among pregnant patients (n=1,219 patients, 47% asymptomatic, 27% mild illness, 14% moderate, 8% severe, and 4% critical) who tested positive for SARS-CoV-2 found that pregnant patients with severe-critical COVID-19 were at higher risk of perinatal complications compared to those with mild or asymptomatic infection, including 6% incidence of venous thromboembolism among those with severe-critical illness compared with 0.2% in mild-moderate and 0% in asymptomatic. In adjusted analyses, severe-critical COVID-19 was associated with increased risk of cesarean birth (aRR=1.6), hypertensive disorders of pregnancy (aRR=1.6), and preterm delivery (aRR=3.5) compared to women with asymptomatic SARS-CoV-2 infection. 

Metz et al. (Feb 8, 2021). Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstetrics and Gynecology. https://pubmed.ncbi.nlm.nih.gov/33560778