February 16, 2021

Longitudinal Analysis of Antibody Response Following SARS-CoV-2 Infection in Pregnancy: From the First Trimester to Delivery

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, pregnancy

In a cohort of 17 SARS-CoV-2 PCR-positive pregnant women followed from the end of the first trimester to delivery, IgG non-neutralizing antibodies (nNAbs) were detected in 71% (12 of 17), while neutralizing antibodies (NAbs) were detected in 53% of individuals (9 of the 12 who seroconverted with IgG nNAbs). Levels of NAbs remained stable throughout pregnancy. In contrast, nNAbs declined over the pregnancy, with a statistically significant decrease observed by week 16.

Cosma et al. (Feb 2, 2021). Longitudinal Analysis of Antibody Response Following SARS-CoV-2 Infection in Pregnancy: From the First Trimester to Delivery. Journal of Reproductive Immunology. https://doi.org/10.1016/j.jri.2021.103285