February 18, 2021

Innate Cell Profiles during the Acute and Convalescent Phase of SARS-CoV-2 Infection in Children

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): children, clinical characteristics

Cell profiles of children (n=48, aged <18 years) with clinically mild SARS-CoV-2 were characterized by reduced circulating subsets of monocytes, dendritic cells, and natural killer cells during the acute phase of infection. In contrast, adults with SARS-CoV-2 infection (n=70) showed reduced proportions of non-classical monocytes only. Both children and adults who were exposed to SARS-CoV-2 but tested PCR negative had higher proportions of low-density neutrophils observed up to 7 weeks post exposure.

Neeland et al. (Feb 17, 2021). Innate Cell Profiles during the Acute and Convalescent Phase of SARS-CoV-2 Infection in Children. Nature Communications https://pubmed.ncbi.nlm.nih.gov/33597531/