Alliance for Pandemic Preparedness

February 22, 2021

Sequelae in Adults at 6 Months After COVID-19 Infection

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A longitudinal prospective cohort study of adults with laboratory-confirmed SARS-CoV-2 infection in Washington State, and a concurrent cohort of healthy (control) patients, found that persistent symptoms were reported up to 9 months after initial infection by 17 of 64 patients (27%) aged 18 to 39 years, 25 of 83 patients (30%) aged 40 to 64 years, and 13 of 30 patients (43%) aged 65 years and older. Overall, 49 of 150 outpatients (33%), 5 of 16 hospitalized patients (31%), and 1 of 21 control participants (5%) reported at least 1 persistent symptom. The most common persistent symptoms were fatigue (14%) and loss of sense of smell or taste (14%). A total of 51 outpatients and hospitalized patients (31%) reported worse health-related quality of life compared with baseline vs only 4 controls and asymptomatic patients (13%). 

Logue et al. (Feb 19, 2021). Sequelae in Adults at 6 Months After COVID-19 Infection. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2021.0830