Alliance for Pandemic Preparedness

March 4, 2021

Non-Steroidal Anti-Inflammatory Agent Use May Not Be Associated with Mortality of Coronavirus Disease 19

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  • In a study of patients with COVID-19 using non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen, there was no significant difference in all-cause mortality between the groups (4% vs 3%, HR=1.33, 95% CI: 0.63-2.88) after using propensity score matching to create comparable groups of treated and untreated patients (n=397 data pairs). There were also no significant differences in usage of mechanical ventilation between NSAID and acetaminophen groups (HR=1.60; 95% CI: 0.53–5.30). The authors suggest that NSAIDs may be used safely among COVID-19 patients.

Park et al. (Mar 3, 2021). Non-Steroidal Anti-Inflammatory Agent Use May Not Be Associated with Mortality of Coronavirus Disease 19. Scientific Reports. https://doi.org/10.1038/s41598-021-84539-5