Alliance for Pandemic Preparedness

March 10, 2021

Factors Linked to Severe Outcomes in Multisystem Inflammatory Syndrome in Children (MIS-C) in the USA: A Retrospective Surveillance Study

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  • A retrospective surveillance study of multisystem inflammatory syndrome in children (MIS-C, n = 1,080 patients) found that ICU admission was more likely in patients aged 6–12 years (aOR = 1.9) and 13–20 years (aOR = 2.6) compared with patients 0–5 years, and more likely in non-Hispanic Black than non-Hispanic White patients (aOR = 1.6). Patients experiencing shortness of breath (aOR = 1.9) and abdominal pain (aOR = 1.7) were also more likely to be admitted to the ICU. Similar associations were found for decreased cardiac function, shock, and myocarditis. Coronary artery abnormalities were more common in male (aOR = 1.5) than female patients and in patients with mucocutaneous lesions (aOR = 2.2) or conjunctival injection (aOR = 2.3).

Abrams et al. (Mar 10, 2021). Factors Linked to Severe Outcomes in Multisystem Inflammatory Syndrome in Children (MIS-C) in the USA: A Retrospective Surveillance Study. The Lancet Child & Adolescent Health. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(21)00050-X/fulltext