Alliance for Pandemic Preparedness

March 12, 2021

Impact of the COVID-19 Vaccine on Asymptomatic Infection Among Patients Undergoing Pre-Procedural COVID-19 Molecular Screening

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  • The risk of asymptomatic SARS-CoV-2 infection was significantly lower among patients who had received at least 1 dose of an mRNA COVID-19 vaccine compared to unvaccinated patients, based on a retrospective cohort study of asymptomatic adult patients (n=39,156) across multiple US states undergoing a pre-procedural SARS-CoV-2 molecular screening test. SARS-CoV-2 was detected in 3% of unvaccinated patients, compared to 1% of participants who had received at least dose prior to screening. After adjusting for age, sex, race/ethnicity and location, the risk for a positive test was significantly lower for patients who had received their first dose >10 days earlier (aRR= 0.49) and those who had received their second dose >0 days (aRR=0.27) compared to unvaccinated patients. 

Tande et al. (Mar 10, 2021). Impact of the COVID-19 Vaccine on Asymptomatic Infection Among Patients Undergoing Pre-Procedural COVID-19 Molecular Screening. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab229