Alliance for Pandemic Preparedness

April 2, 2021

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

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  • 4 cases of possible SARS-CoV-2 reinfection characterized by a more severe second episode were identified in a case series in Brazil. In March 2020, all patients recovered from a mild course of COVID-19 and retested with negative PCR results during early April. In the last week of May, all 4 cases reported SARS-CoV-2 symptoms and had higher viral loads and worse clinical symptoms than they did in March. Sequenced genomes from the second episode compared to those obtained in the first episode and prior circulating variants suggest that reinfection was caused by different strains.

Fintelman-Rodrigues et al. (Apr 1, 2021). Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerging Infectious Disease Journal. https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article