Alliance for Pandemic Preparedness

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Tag: reinfection

May 17, 2021

Risk of SARS-CoV-2 Reinfection in a University Student Population

The risk of SARS-CoV-2 reinfection among college students with prior infection was 2.2% (n = 16,101, 2,021 with and 14,080 without previous infection), while estimated protection from previous infection was 84% among students tested in fall 2020 and spring 2021 semesters at a large university in South Carolina. All students with access to main campus…

April 2, 2021

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

4 cases of possible SARS-CoV-2 reinfection characterized by a more severe second episode were identified in a case series in Brazil. In March 2020, all patients recovered from a mild course of COVID-19 and retested with negative PCR results during early April. In the last week of May, all 4 cases reported SARS-CoV-2 symptoms and…

March 25, 2021

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

SARS-CoV-2 reinfection with a variant harboring the E484K mutation (occurring in the P.2 variant) was confirmed by genome sequencing in a case study in Brazil. The primary infection occurred in May 2020 by a widely circulating variant B.1.1.33 without the E484K mutation, while the reinfection occurred 147 days later in October 2020. Findings from this…

March 23, 2021

Risk of Reinfection after Seroconversion to SARS-CoV-2 A Population-Based Propensity-Score Matched Cohort Study

[Pre-print, not peer-reviewed] Swiss adults who were seropositive for SARS-CoV-2 IgG antibodies were less likely to have a SARS-CoV-2 PCR positive test than propensity-score-matched seronegative adults in the 8 months following antibody measurements. Of the 498 seropositive individuals, only 5 (1%) retested positive (likely indicative of reinfection) after a mean follow-up of 36 weeks. In…

March 18, 2021

Assessment of Protection against Reinfection with SARS-CoV-2 among 4 Million PCR-Tested Individuals in Denmark in 2020: A Population-Level Observational Study

Individuals with a positive SARS-CoV-2 PCR test during the first surge in Denmark (prior to June 2020) were less likely to get a positive test during the second surge (September to December 2020) compared to individuals with a negative SARS-CoV-2 PCR test during the first surge. In this nationwide cohort study (n=525,339), 72 of 11,068…

March 16, 2021

Reinfection Rates among Patients Who Previously Tested Positive for COVID-19: A Retrospective Cohort Study

Previous SARS-COV-2 infection was associated with a lower likelihood of subsequent reinfection compared to those without a previous history of infection. These results are based on a cohort study of over 150,000 patients from a multi-hospital system in Ohio and Florida. Among 8,845 initially PCR-positive patients, 1,278 were retested after ≥90 days and 62 (0.4%)…

March 15, 2021

A Follow-up Study Shows That Recovered Patients with Re-Positive PCR Test in Wuhan May Not Be Infectious

A follow-up study analyzing data from 20,280 COVID-19 patients from multiple centers in Wuhan, China who received a positive PCR result between December 2019 and August 2020 found that 2,466 (12.2%) patients tested positive again (2,238 of were asymptomatic) after being discharged from the hospital. None of the 4,079 close contacts of patients who tested…

February 19, 2021

Clinical and Laboratory Findings in Patients with Potential SARS-CoV-2 Reinfection, May-July 2020

A clinical and laboratory investigation of potential SARS-CoV-2 reinfection reported to CDC by clinicians in the US did not confirm any cases of reinfection within 90 days of the initial infection, supporting current CDC guidance about retesting for people recovered from COVID-19. Among 73 potential reinfection patients with available records, 70% of patients either had…

January 20, 2021

Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers Large Multi-Centre Prospective Cohort Study (the SIREN Study) England June to November 2020

Prior history of SARS-CoV-2 infection was associated with an 83% lower risk of infection in a large, multicenter, prospective cohort study (SIREN) of healthcare workers in England, with median protective effect observed five months following primary infection. The incidence between June 18-November 9, 2020 was 3.3 reinfections per 100,000 person days in the previously-infected cohort,…

December 28, 2020

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

The presence of SARS-CoV-2 anti-spike or anti-nucleocapsid IgG antibodies was associated with a reduced risk of SARS-CoV-2 reinfection over 6 months of follow-up among health care workers in the UK (n=12,541). The risk of testing positive for SARS-CoV-2 by PCR during study follow-up was 1.09 per 10,000 person-days at risk among workers who were negative…

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