April 8, 2021

Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7 Role of the P681H Mutation

Category: Article Summary

Topic: Transmission

Keywords (Tags): transmission, variants

• [Pre-print, not peer-reviewed] In vitro experiments show that while the P681H mutation found in the SARS-CoV-2 B.1.1.7 variant was associated with more efficient cleavage of the Spike 1 and Spike 2 (S1/S2) subunits, this did not translate to a significant impact on cell entry or an increase in cell-to- cell spread.

Lubinski et al. (Apr 8, 2021). Functional Evaluation of Proteolytic Activation for the SARS-CoV-2 Variant B.1.1.7 Role of the P681H Mutation. Pre-print downloaded Apr 8 from https://doi.org/10.1101/2021.04.06.438731