Alliance for Pandemic Preparedness

April 14, 2021

The Balancing Role of Distribution Speed against Varying Efficacy Levels of COVID-19 Vaccines under Variants

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  • [Pre-print, not peer-reviewed] Vaccines with lower efficacy can reduce population-level transmission more than vaccines with higher efficacy if distribution of lower efficacy vaccines was comparatively faster based on findings from a modeling study. A vaccine with 65% and 60% efficacy before and after the variants, respectively, can outperform a vaccine with 95% and 90% efficacy, if its distribution were 46-48% faster. The authors state that these results have implications for vaccine distribution strategies in the face of an increasing proportion of infections with SARS-CoV-2 known and future variants against which current vaccines may have lower efficacy.

Kim et al. (Apr 13, 2021). The Balancing Role of Distribution Speed against Varying Efficacy Levels of COVID-19 Vaccines under Variants. Pre-print downloaded Apr 14 from https://doi.org/10.1101/2021.04.09.21255217