April 22, 2021

Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): pregnancy

• In an international cohort study, pregnant women with COVID-19 (n=706) were at increased risk for preeclampsia/eclampsia, severe infections, ICU admissions, preterm birth, severe neonatal morbidity and severe perinatal morbidity and mortality compared to those without a COVID-19 diagnosis (n=1,424). Asymptomatic SARS-CoV-2 infection was only associated with increased risk for maternal morbidity and preeclampsia. 13% of neonates delivered from PCR-positive women also tested positive. Cesarean delivery, but not breastfeeding, was significantly associated with neonatal test positivity. Infants who tested positive for SARS-CoV-2 had considerably higher risk of requiring neonatal intensive care (RR=6, 3.3-10.9).

Villar et al. (Apr 22, 2021). Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2021.1050