Alliance for Pandemic Preparedness

May 13, 2021

Adverse Pregnancy Outcomes, Maternal Complications, and Severe Illness among U.S. Delivery Hospitalizations with and without a COVID-19 Diagnosis

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  • Adverse pregnancy outcomes occurred more frequently among US women with documented COVID-19 diagnosis at delivery hospitalization compared to those without diagnosis (4.4% vs 0.8%) in a large study including 703 hospitals (n=489,471 delivery hospitalizations; 1.3% of patients with COVID-19) between March and September 2020. In analyses adjusted for confounders, COVID-19 diagnosis was associated with a 1.2-fold increase in risk of any adverse pregnancy outcome, including preterm delivery and stillbirth, and a 6.3-fold increase in risk of any maternal complication, including sepsis and shock. Discharge to home did not differ by COVID-19 status.

Ko et al. (May 12, 2021). Adverse Pregnancy Outcomes, Maternal Complications, and Severe Illness among U.S. Delivery Hospitalizations with and without a COVID-19 Diagnosis. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab344