May 21, 2021

Efficient Maternal to Neonatal Transfer of Antibodies against SARS-CoV-2 and BNT162b2 MRNA COVID-19 Vaccine

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): pregnancy, vaccination

• A multicenter study of pregnant persons in Israel (N=213) found that the Pfizer-BioNTech vaccine elicited strong maternal IgG response and produced similar IgG titers in the fetus 15 days after the first dose. Among study participants who were infected with SARS-CoV-2 during pregnancy, those infected in the third trimester had lower rates of antibody transfer across the placenta compared to those infected in their second trimester. The authors suggest these results support vaccination during pregnancy to protect the pregnant person and fetus from SARS-CoV-2 infection.

Beharier et al. (May 20, 2021). Efficient Maternal to Neonatal Transfer of Antibodies against SARS-CoV-2 and BNT162b2 MRNA COVID-19 Vaccine. Journal of Clinical Investigation. https://doi.org/10.1172/JCI150319