May 27, 2021

Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): children, clinical characteristics

• In a cohort study of individuals aged <18 years who were hospitalized with COVID-19 (n=32), those diagnosed with multisystem inflammatory syndrome in children (MIS-C) (n=16) had significantly higher levels of cytokine and chemokines, such as IL-6 and IL-8, and were more likely to have anti-SARS-CoV-2 antibody positivity (75% vs 44%) compared to those without MIS-C. MIS-C patients tended to be younger (median age 2.2 years vs 8.7 years), but nasopharyngeal viral load did not differ significantly between the two groups.

Akindele et al. (May 24, 2021). Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiab285