May 27, 2021

Type I, II, and III Interferon Signatures Correspond to COVID-19 Disease Severity

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics, immune response, other resources

• In an analysis of plasma levels of interferons (IFNs) and cytokines among patients with SARS-CoV-2 infection and varying disease severity (n=67), type I IFN responses appeared to be transient among those with mild disease but prolonged among those admitted to the ICU. Plasma levels of type II IFNs were comparable among patients overall and induced early in disease course. Like type I IFNs, cytokine and chemokine levels correlated with disease severity and were highest in ICU patients. 

Kim et al. (May 24, 2021). Type I, II, and III Interferon Signatures Correspond to COVID-19 Disease Severity. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiab288