Alliance for Pandemic Preparedness

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May 27, 2021

Type I, II, and III Interferon Signatures Correspond to COVID-19 Disease Severity

In an analysis of plasma levels of interferons (IFNs) and cytokines among patients with SARS-CoV-2 infection and varying disease severity (n=67), type I IFN responses appeared to be transient among those with mild disease but prolonged among those admitted to the ICU. Plasma levels of type II IFNs were comparable among patients overall and induced…

February 9, 2021

Emergence of an Early SARS-CoV-2 Epidemic in the United States

[Pre-print, not peer-reviewed] Genome sequencing combined with epidemiological and mobility data suggest show that SARS-COV-2 was likely introduced in Louisiana from a single source via domestic travel and was being locally spread prior to the Mardi Gras celebrations in February 2020. However, further evidence suggests that Mardi Gras was likely a superspreading event, based on…

January 20, 2021

Epidemiology of Coronavirus Disease 2019 in US Immigration and Customs Enforcement Detention Facilities

COVID-19 incidence among people detained by US Immigration and Customs Enforcement (ICE) was higher than the incidence in the US general population, with an overall incidence of 214 per 1,000 people (5,810 cases among 27,189 people), with 6 deaths reported. The incidence was higher than in the general population in the surrounding county in 20…

January 12, 2021

Bidirectional Contact Tracing Could Dramatically Improve COVID-19 Control

A modeling study found that bi-directional contact tracing could double the reduction in effective reproductive number (Reff) compared to conventional forward-tracing alone. Bi-directional contact tracing identifies potential infectors of known cases, which could lead to identification of additional cases arising from the potential infectors. The authors also suggest expanding the tracing window from 2-6 days…