Alliance for Pandemic Preparedness

June 7, 2021

The Role of HIV Infection in the Clinical Spectrum of COVID-19 a Population-Based Cohort Analysis Based on US National COVID Cohort Collaborative (N3C) Enclave Data

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  • [Pre-print, not peer-reviewed] A study using electronic health record data from 54 clinical sites in the National COVID Cohort Collaborative found that people living with HIV (PLWH, n=13,170) had a higher risk of COVID-19 death and hospitalization after adjusting for age and sex. The associations were attenuated, but remained significant, after adjusting for smoking status, BMI, and comorbidities (death aOR = 1.4, hospitalization = 1.2). PLWH were more likely to have severe COVID-19 when only controlling for demographics, smoking, and BMI, although the estimated risk was obviated after controlling for comorbidities. Analysis for effect modification found that the HIV-associated risk was higher among older people, males, and Black/African American individuals. 

Yang et al. (June 6, 2021). The Role of HIV Infection in the Clinical Spectrum of COVID-19 a Population-Based Cohort Analysis Based on US National COVID Cohort Collaborative (N3C) Enclave Data. Pre-print downloaded Jun 7 from https://doi.org/10.1101/2021.06.03.21258324