Alliance for Pandemic Preparedness

June 10, 2021

Optimizing Vaccine Allocation for COVID-19 Vaccines Shows the Potential Role of Single-Dose Vaccination

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  • A model optimizing COVID-19 vaccine allocation calibrated to Washington State found that with high single-dose efficacy (>65%) and low baseline transmission, single-dose vaccination in all adults is optimal and can prevent up to 22% more deaths compared to a strategy prioritizing two-dose vaccination for older adults. However, under low single-dose efficacy (20%) and high transmission scenarios, two-dose vaccination prioritizing older adults can prevent up to 41% more deaths compared to single-dose vaccination in all adult populations. [EDITORIAL NOTE: A pre-print related to this manuscript was summarized on January 6, 2021.]

Matrajt et al. (June 8, 2021). Optimizing Vaccine Allocation for COVID-19 Vaccines Shows the Potential Role of Single-Dose Vaccination. Nature Communications. https://doi.org/10.1038/s41467-021-23761-1